Bujila Ioana, Jansson-Mörk Marie, Nederby-Öhd Joanna, Hansen Anette, Lindblad Mats, Fischerstöm Karolina, Bragd Matilda, Hall Ingela, Lindroos Nilla, Rönnberg Caroline, Rehn Moa, Beser Jessica
Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Euro Surveill. 2025 Jul;30(26). doi: 10.2807/1560-7917.ES.2025.30.26.2400643.
In Sweden, an increase in the number of notified cases of cryptosporidiosis was observed 1 October-31 December 2019 (462 domestic cases). Although a single national outbreak was initially suspected, molecular and epidemiological analyses revealed two concurrent national outbreaks and three local outbreaks. subtype IIdA22G1c and IIdA24G1 were identified as the cause of the national outbreaks and subtype IIdA20G1e and IIdA21G1 as the cause of the local outbreaks. A case-case study comparing exposures in IIdA22G1c to IIdA24G1 revealed that cases with subtype IIdA22G1c (n = 48) were associated with consumption of a fresh fruit-and-vegetable juice (adjusted odds ratio (aOR) = 17; 95% confidence interval (CI): 1.8-169; p = 0.002). In the local outbreaks with subtype IIdA20G1e and IIdA21G1, cohort studies suggested that cases were associated with consumption of salads. Several coinciding outbreaks with different subtypes explained the increase of cryptosporidiosis, and molecular typing was crucial in guiding relevant cross-disciplinary collaboration.
在瑞典，2019年10月1日至12月31日期间报告的隐孢子虫病病例数有所增加（462例本土病例）。尽管最初怀疑是全国性的单一疫情，但分子和流行病学分析显示同时发生了两起全国性疫情和三起局部疫情。IIdA22G1c和IIdA24G1亚型被确定为全国性疫情的病因，IIdA20G1e和IIdA21G1亚型为局部疫情的病因。一项比较IIdA22G1c和IIdA24G1暴露情况的病例对照研究表明，IIdA22G1c亚型病例（n = 48）与饮用新鲜果蔬汁有关（调整后的优势比（aOR）= 17；95%置信区间（CI）：1.8 - 169；p = 0.002）。在IIdA20G1e和IIdA21G1亚型的局部疫情中，队列研究表明病例与食用沙拉有关。几起不同亚型的同时爆发解释了隐孢子虫病病例数的增加，分子分型对于指导相关跨学科合作至关重要。
