Requena C, Manrique E, Nagore E
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.
Actas Dermosifiliogr. 2023 May;114(5):T413-T424. doi: 10.1016/j.ad.2023.04.023. Epub 2023 Apr 20.
Lentigo maligna is an in situ cutaneous melanoma that arises in sun-damaged skin. Its most common presentation is a progressive, slow-growing, irregularly pigmented spot on the face of older patients. Although the exact percentage of lentigo maligna that progresses to invasive tumors is unknown, it is thought to lie between 2% and 5%. Both the clinical and histologic diagnosis of lentigo maligna can be challenging, especially in patients with early-stage or atypical disease. Treatment also holds challenges, because lesions are located in highly visible areas and are often large. Surgery can thus compromise cosmetic and sometimes functional outcomes. We review clinical and histopathological findings that can facilitate the diagnosis of lentigo maligna. We also examine treatment options, with a focus on surgery.
恶性雀斑样痣是一种原位皮肤黑色素瘤,发生于受阳光损伤的皮肤。其最常见的表现是老年患者面部出现一个进行性、生长缓慢、色素沉着不规则的斑点。尽管恶性雀斑样痣进展为浸润性肿瘤的确切百分比尚不清楚,但据认为在2%至5%之间。恶性雀斑样痣的临床和组织学诊断都可能具有挑战性,尤其是在早期或非典型疾病患者中。治疗也存在挑战,因为病变位于高度可见的区域且通常较大。因此,手术可能会影响美容效果,有时还会影响功能。我们回顾了有助于诊断恶性雀斑样痣的临床和组织病理学发现。我们还研究了治疗选择,重点是手术。