Conlay L A, Karam J H, Matin S B, Loewenstein J E
Diabetes. 1977 Jul;26(7):628-31. doi: 10.2337/diab.26.7.628.
Phenformin concentrations were measured in serum from seven patients with phenformin-associated lactic acidosis, and initial values ranging from 20 to 625 ng./ml. were obtained. Five of the seven patients had serum concentrations within the usual therapeutic range of up to 241 ng./ml. Serum phenformin concentrations were measured serially, and apparent half-lives of 5, 25, and 30 hours were obtained in three patients with serum creatinine concentrations of 1.7, 7.6, and 6.0 mg./dl., respectively. Although the half-life of phenformin was prolonged in azotemic patients, no correlation between serum creatinine concentration and serum phenformin could be demonstrated; furthermore, the severity of lactic acidosis as measured by arterial pH and lactate concentration did not correlate with the serum creatinine concentration.
对7例苯乙双胍相关性乳酸性酸中毒患者的血清进行了苯乙双胍浓度测定，初始值为20至625纳克/毫升。7例患者中有5例血清浓度在高达241纳克/毫升的常规治疗范围内。对血清苯乙双胍浓度进行了连续测定，血清肌酐浓度分别为1.7、7.6和6.0毫克/分升的3例患者的表观半衰期分别为5、25和30小时。虽然氮质血症患者中苯乙双胍的半衰期延长，但血清肌酐浓度与血清苯乙双胍之间未显示出相关性；此外，通过动脉血pH值和乳酸浓度测定的乳酸性酸中毒严重程度与血清肌酐浓度无关。
