PURPOSE: Structural racism and homonegativity influence access to housing and shape the HIV risk environment. We assess disparities in mortgage loan denial and evaluate the association of intersectional mortgage discrimination with HIV incidence among sexual minority men (SMM) across U.S. counties. METHODS: Using loan applications from 2018-2022, we conducted a decomposition analysis to measure national disparities in mortgage denial by race and sexual orientation. We then constructed a county-level measure of mortgage discrimination against Black same-sex male couples using mixed-effects logistic regression, and we evaluated its association with HIV incidence among SMM in 2022 using Poisson regression adjusted for county-level covariates. RESULTS: Mortgage loan denial was 14.9 percentage points higher among Black same-sex couples (22.0 %) than White heterosexual couples (7.1 %). HIV incidence rate among SMM was 26 % [95 % CI: 22, 30] higher in counties in the highest versus lowest tertile of intersectional mortgage discrimination. CONCLUSIONS: Contemporary forces of structural racism and homonegativity continue to influence housing access, evidenced by higher loan denial for Black same-sex male couples versus White heterosexual couples. Such discrimination may contribute to the population-level burden of HIV. Anti-discrimination policies that increase access to housing for Black sexual minority men may aid in addressing HIV inequities.