对映选择性异硫脲催化由芳基酯生成的C1-铵烯醇盐的α-氟化反应。
Enantioselective isothiourea-catalysed α-fluorination of C1-ammonium enolates generated from arylesters.
作者信息
Stanek Nicole, Stockhammer Lotte, Moser Anja, Waser Mario
机构信息
Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz, Austria.
出版信息
J Fluor Chem. 2025 Apr;283-284:110434. doi: 10.1016/j.jfluchem.2025.110434.
Abstract
We herein report the chiral isothiourea-catalyzed α-fluorination of electron-deficient arylesters. This transformation proceeds via the in situ formation of chiral C1-ammonium enolates, which then undergo the α-fluorination with high levels of enantioselectivities, followed by addition of alcohols, such as MeOH, to give the final chiral α-F-esters.
摘要
我们在此报告手性异硫脲催化的缺电子芳基酯的α-氟化反应。该转化过程通过手性C1-铵烯醇盐的原位形成进行，然后这些烯醇盐以高对映选择性进行α-氟化反应，接着加入醇类，如甲醇，得到最终的手性α-F-酯。
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