Chen Yuequn, Wu Guiqiong, Qu Chaojun, Ye Zimao, Kang Yihao, Tian Xin
Department of Intensive Care Unit, Fifth Affiliated Hospital of Wenzhou Medical University; Lishui Municipal Central Hospital, Lishui, 323000, People's Republic of China.
Int J Gen Med. 2025 Jul 2;18:3609-3626. doi: 10.2147/IJGM.S523748. eCollection 2025.
The impact of complications and long-term outcomes remains unclear for endoscopy-guided nasojejunal feeding tube (ENFT) placement versus blind nasogastric feeding tube (BNFT) placement on post-COVID-19 ICU patients.
A retrospective cohort study comparing BNFT and ENFT placement in ICU patients post-COVID-19 infection.
To evaluate the impact of BNFT versus ENFT placement methods on complications in post-COVID-19 ICU patients requiring enteral feeding.
A total of 310 ICU patients were retrospectively analyzed after applying inclusion and exclusion criteria, comprising 99 patients in the ENFT group and 211 patients in the BNFT group.
The study was conducted in the intensive care units of a tertiary care hospital from September 2023 to November 2023.
Primary outcomes included baseline clinical characteristics and symptoms prior to COVID-19 infection. Secondary outcomes assessed post-COVID-19 complications over short (up to 2 weeks), medium (2-4 weeks), and long-term (beyond 4 weeks) periods. These complications included shortness of breath, cognitive dysfunction, muscle and joint pain, sleep disturbances, and gastrointestinal symptoms, measured by GSRS and SAQ scores.
Baseline characteristics were similar between both groups (p > 0.05), indicating well-matched cohorts. Post-COVID-19, the ENFT group exhibited significantly lower rates of shortness of breath, cognitive dysfunction, muscle and joint pain, sleep disturbances, and mental health challenges, especially for long-term feeding tube usage (p < 0.05). GSRS scores were lower and SAQ scores were higher in the ENFT group, indicating better gastrointestinal and cardiovascular outcomes.
ENFT placement is associated with fewer post-COVID-19 complications compared to BNFT, particularly for patients requiring long-term feeding tube usage in the ICU.
对于新冠肺炎重症监护病房（ICU）患者，内镜引导下鼻空肠喂养管（ENFT）置入与盲目鼻胃喂养管（BNFT）置入相比，并发症和长期预后的影响仍不明确。
一项回顾性队列研究，比较新冠肺炎感染后ICU患者的BNFT和ENFT置入情况。
评估BNFT与ENFT置入方法对需要肠内营养的新冠肺炎后ICU患者并发症的影响。
在应用纳入和排除标准后，对310例ICU患者进行回顾性分析，其中ENFT组99例，BNFT组211例。
该研究于2023年9月至2023年11月在一家三级医院的重症监护病房进行。
主要指标包括新冠肺炎感染前的基线临床特征和症状。次要指标评估新冠肺炎后短期（最长2周）、中期（2 - 4周）和长期（超过4周）的并发症。这些并发症包括呼吸急促、认知功能障碍、肌肉和关节疼痛、睡眠障碍以及胃肠道症状，通过胃肠道症状评分量表（GSRS）和西雅图心绞痛量表（SAQ）评分进行测量。
两组的基线特征相似（p > 0.05），表明队列匹配良好。新冠肺炎后，ENFT组呼吸急促、认知功能障碍、肌肉和关节疼痛、睡眠障碍以及心理健康问题的发生率显著较低，尤其是长期使用喂养管的情况（p < 0.05）。ENFT组的GSRS评分较低，SAQ评分较高，表明胃肠道和心血管结局更好。
与BNFT相比，ENFT置入与新冠肺炎后并发症较少相关，特别是对于ICU中需要长期使用喂养管的患者。
