Ernest J T, Stern W H, Trimble J L
Invest Ophthalmol Vis Sci. 1977 Jul;16(7):670-3.
Mannitol administered intravenously in rhesus monkeys resulted in a temporary recovery of the visual evoked response (VER) after its decrease due to elevation of the intraocular pressure. Mannitol infusion caused an immediate, albeit transitory, increase in retinal oxygen tension. These changes were independent of the ocular hypotensive effect of mannitol, and we conclude that the drug is a far better agent for the treatment of acute glaucoma than heretofore believed.
在恒河猴中静脉注射甘露醇,可使其因眼压升高而降低的视觉诱发电位(VER)暂时恢复。输注甘露醇会立即引起视网膜氧张力升高,尽管这种升高是短暂的。这些变化与甘露醇的降眼压作用无关,我们得出结论,该药物作为急性青光眼的治疗药物,比以往认为的要好得多。