Chen Ruijin, Jin Lihua, Song Jin, Dong Juchuan, Li Yongmei
Department of Rehabilitation Therapy, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Department of Rehabilitation Medicine, Kunming Medical University, Kunming, Yunnan, China.
Brain Behav. 2025 Jul;15(7):e70671. doi: 10.1002/brb3.70671.
Although the role of sensory input in maintaining balance is well established, the effects of various auditory frequency stimulations, such as binaural beat stimulation (BBS), on patients with central nervous system injuries, particularly those who have experienced a stroke, remain inadequately understood.
This randomized case-control study compared the functional outcomes between patients with stroke undergoing BBS during rehabilitation training and those receiving traditional music therapies. The assessed primary outcomes included balance function, balance confidence, lower-limb function, and activities of daily living, cognitive abilities, and depression scores. Subsequently, correlations between outcome parameters were analyzed.
A total of 27 patients with stroke completed the study protocol (BBS n = 15, control n = 12). Post-intervention analyses revealed improvements in balance-related indicators, particularly the scores of the Berg Balance Scale (BBSc) and Mini-Balance Evaluation Systems Test (Mini-BESTest), across both groups. However, the Barthel index (BI) and Beck depression inventory scores (BDIS) in the BBS group exhibited significantly greater improvements than those in the control group. Correlation analyses indicated that changes in balance-related scores within the BBS group were associated with improvements in lower-limb function, mood, and activities of daily living. Conversely, the control group observed correlations among the internal components of the balance-related scales.
Appropriate BBS stimulation appears to enhance balance, likely owing to the synergistic effects of music and rhythm. Further research focusing on brain function is necessary to elucidate the mechanisms underlying the therapeutic efficacy of BBS interventions.
尽管感觉输入在维持平衡中的作用已得到充分证实，但各种听觉频率刺激，如双耳节拍刺激（BBS），对中枢神经系统损伤患者，尤其是中风患者的影响仍未得到充分了解。
本随机病例对照研究比较了康复训练期间接受BBS的中风患者与接受传统音乐疗法的患者的功能结局。评估的主要结局包括平衡功能、平衡信心、下肢功能、日常生活活动能力、认知能力和抑郁评分。随后，分析了结局参数之间的相关性。
共有27例中风患者完成了研究方案（BBS组n = 15，对照组n = 12）。干预后分析显示，两组的平衡相关指标均有改善，尤其是伯格平衡量表（BBSc）和迷你平衡评估系统测试（Mini - BESTest）的得分。然而，BBS组的巴氏指数（BI）和贝克抑郁量表评分（BDIS）的改善明显大于对照组。相关性分析表明，BBS组内平衡相关评分的变化与下肢功能、情绪和日常生活活动能力的改善有关。相反，对照组观察到平衡相关量表内部各成分之间存在相关性。
适当的BBS刺激似乎能增强平衡，这可能归因于音乐和节奏的协同作用。有必要进一步开展针对脑功能的研究，以阐明BBS干预治疗效果的潜在机制。
