较高的C反应蛋白/白蛋白比值是预测糖尿病足感染患者截肢的一个潜在标志物。
Higher C-reactive protein/albumin ratio is a potential marker for predicting amputation in patients with diabetic foot infection.
作者信息
Zhang Li, Gao Xufeng, He Meifang, Wang Wenyan, Zhao Yuebin
机构信息
Department of Endocrinology, Taiyuan City Central Hospital, Taiyuan, Shanxi, China.
Department of General Surgery, Children's Hospital of Shanxi, Taiyuan, Shanxi, China.
出版信息
Arch Endocrinol Metab. 2025 Jul 7;69(3):e240397. doi: 10.20945/2359-4292-2024-0397.
OBJECTIVE
Non-traumatic amputation resulting from diabetic foot infection (DFI) poses significant clinical and public health concerns. The C-reactive protein (CRP)/albumin ratio represents a combination of the infection level and nutritional status. This study investigated the relationship between the CRP/albumin ratio and amputation in patients with diabetic foot infections.
SUBJECTS AND METHODS
Patients with a DFI of Wagner grade. 3 diagnosed between January 2020 and September 2023 were retrospectively analyzed. The association between the CRP/albumin ratio and amputation was explored using multivariable logistic regression modeling. Stratified analyses were also performed to ensure the reliability of the findings.
RESULTS
Of 301 enrolled patients, 226 underwent amputation and 75 did not. The amputation rate increased with a greater CRP/albumin ratio in the non-adjusted, minimally adjusted, and fully adjusted models, regardless of whether the CRP/albumin ratio was regarded as a categorical or continuous variable.
CONCLUSION
An increased CRP/albumin ratio was associated with a greater risk of amputation in individuals with DFI.
目的
糖尿病足感染（DFI）导致的非创伤性截肢引起了重大的临床和公共卫生问题。C反应蛋白（CRP）/白蛋白比值代表了感染水平和营养状况的综合情况。本研究调查了糖尿病足感染患者中CRP/白蛋白比值与截肢之间的关系。
对象与方法
回顾性分析2020年1月至2023年9月期间诊断为Wagner分级3级的糖尿病足感染患者。使用多变量逻辑回归模型探讨CRP/白蛋白比值与截肢之间的关联。还进行了分层分析以确保研究结果的可靠性。
结果
在301名纳入研究的患者中，226例行截肢手术，75例未行截肢手术。在未调整、最小调整和完全调整模型中，无论CRP/白蛋白比值被视为分类变量还是连续变量，截肢率均随着CRP/白蛋白比值的升高而增加。
结论
CRP/白蛋白比值升高与糖尿病足感染患者截肢风险增加有关。
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