Çağdaş Serhat, Şengör Neslihan Serap
Electrical-Electronics Engineering Department, Yalova University, Çınarcık Yolu, Yalova, 77200, Türkiye.
Electronics and Communication Engineering Department, Istanbul Technical University, Maslak, Istanbul, 34469, Türkiye.
Biol Cybern. 2025 Jul 7;119(4-6):18. doi: 10.1007/s00422-025-01016-2.
The basal ganglia make a significant contribution to the generation of motor behavior through their involvement in the descending motor pathways. Gaining insight into how the motor cortex produces motor patterns is also a key to understanding the function of the basal ganglia. The population dynamics approach is convenient for the reevaluation of the behavior of the motor cortex and also the roles of other components in the motor system. Here, it is proposed that the basal ganglia amplify preparatory activity in the motor cortex with the modulatory effect of phasic dopamine release. The influence of the basal ganglia is tested with a computational model on a center-out-reaching task. The results show that the basal ganglia facilitate movement initiation and increase the robustness of the behavior. These results, based on the perspective of population dynamics, may improve our understanding of the role of the basal ganglia in motor control and the symptoms of dopamine-related conditions in neurodegenerative diseases of motor control.
基底神经节通过参与下行运动通路，对运动行为的产生做出了重要贡献。深入了解运动皮层如何产生运动模式也是理解基底神经节功能的关键。群体动力学方法便于重新评估运动皮层的行为以及运动系统中其他组件的作用。在此，有人提出基底神经节通过阶段性多巴胺释放的调节作用，增强运动皮层中的准备活动。利用一个计算模型在中心向外伸展任务中测试了基底神经节的影响。结果表明，基底神经节促进运动发起并增强行为的稳健性。这些基于群体动力学视角的结果，可能会增进我们对基底神经节在运动控制中的作用以及运动控制神经退行性疾病中多巴胺相关病症症状的理解。
