[Study of the growth of Streptomyces rimosus cultures during controlled biosynthesis of oxytetracycline using differential sucrose density gradient centrifugation].

The developmental characteristics of the oxytetracycline-producing organism were studied with differential centrifuging over the sucrose density gradient. It was shown that the fermentation broth of Streptomyces rimosus is divided into 7 mycelial fractions and only 2 of them are capable of biosynthesis of oxytetracycline. During controlled biosynthesis of oxytetracycline the mycelium content in these fractions was higher.