[Comparative study of the effect of aeration conditions on the biosynthesis of oxytetracycline by an actinomyces rimosus culture and of lincomycin by an Actinomyces roesolus culture].

The effect of aeration conditions on growth of the oxytetracycline- and lincomycin-producing organisms and antibiotic biosynthesis was studied. It was shown that the lincomycin-producing organism respiration rate was much higher and required better aeration condition-than the oxytetracycline-producing organism. The highest respiration rate of the young myces lium was observed in the growth phase. During the period of the antibiotic biosynthesis the rate of oxygen consumption somewhat decreased though remained sufficiently high. Decreased productivity of the mycelium at the end of the process was accompanied by a drop in the respiration rate. The lack of oxgen lowered the mycelium productivity with respect to the antibiotic formation to a much much greater extent than the culture growth rate. The limiting of the antibiotic biosynthesis process by the lack of dissolved oxygen was accompanied by changes in the culture metabolism evident from production of organic acids: ketoacids and volatile acids by Act. rimosus and volatile and lactic acids by Act. roseolus.