[发酵液氧化还原电位对土霉素生物合成的影响]
[Effect of redox potential of culture broth on oxytetracycline biosynthesis].
作者信息
Vlasov V I
出版信息
Antibiot Khimioter. 1996 Apr;41(4):23-9.
The influence of the redox potential on the biosynthesis of oxytetracycline was studied. It was shown that during the first hours of the Streptomyces rimosus cultivation Eh decreased to the negative values. There was detected a relationship between Eh within the negative values and the antibiotic production: the lower Eh, the lower the antibiotic content in the fermentation broth by the end of the process. It was noted that the Eh value during the first days of the fermentation determined the level of the antibiotic production for the entire cycle of the biosynthesis regardless of the further cultivation conditions.
研究了氧化还原电位对土霉素生物合成的影响。结果表明，在龟裂链霉菌培养的最初几个小时内，氧化还原电位（Eh）降至负值。在负值范围内检测到Eh与抗生素产量之间存在关系：Eh越低，发酵过程结束时发酵液中抗生素含量越低。值得注意的是，发酵最初几天的Eh值决定了生物合成整个周期的抗生素产量水平，而与后续培养条件无关。
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