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你的肾脏还好吗?早检测以保护肾脏健康。

Are Your kidneys ok? Detect early to protect kidney health.

作者信息

Vassalotti Joseph A, Francis Anna, Santos Augusto Cesar Soares Dos, Correa-Rotter Ricardo, Abdellatif Dina, Hsiao Li-Li, Roumeliotis Stefanos, Haris Agnes, Kumaraswami Latha A, Lui Siu-Fai, Balducci Alessandro, Liakopoulos Vassilios

机构信息

Mount Sinai Hospital, Department of Medicine-Renal Medicine, NY, New York, United States.

Queensland Children's Hospital, Department of Nephrology, South Brisbane, Queensland, Australia.

出版信息

J Bras Nefrol. 2025 Oct-Dec;47(4):e20250106. doi: 10.1590/2175-8239-JBN-2025-0106en.

Abstract

Early identification of kidney disease can protect kidney health, prevent kidney disease progression and related complications, reduce cardiovascular disease risk, and decrease mortality. We must ask "Are your kidneys ok?" using serum creatinine to estimate kidney function and urine albumin to assess for kidney and endothelial damage. Evaluation for causes and risk factors for chronic kidney disease (CKD) includes testing for diabetes and measurement of blood pressure and body mass index. On this World Kidney Day, we emphasize that case-finding in high-risk populations or even population level screening can decrease the burden of kidney disease globally. Early-stage CKD is asymptomatic, simple to test for, and recent paradigm shifting CKD treatments such as sodium glucose co-transporter-2 inhibitors dramatically improve outcomes and favor the cost-benefit analysis for screening or case-finding programs. Despite this, numerous barriers exist, including resource allocation, healthcare funding, healthcare infrastructure, and awareness of kidney disease among healthcare professionals and the general population. Coordinated efforts by major kidney non-governmental organizations to prioritise the kidney health agenda for governments and align early detection efforts with other current programs will maximise efficiency.

摘要

早期识别肾脏疾病可以保护肾脏健康,预防肾脏疾病进展及相关并发症,降低心血管疾病风险,并降低死亡率。我们必须通过检测血清肌酐以评估肾功能、检测尿白蛋白以评估肾脏及内皮损伤,来询问“你的肾脏还好吗?”。对慢性肾脏病(CKD)病因及危险因素的评估包括检测糖尿病以及测量血压和体重指数。在今年的世界肾脏日,我们强调在高危人群中开展病例筛查甚至进行人群层面的筛查,能够减轻全球肾脏疾病负担。早期CKD没有症状,检测简单,并且近期诸如钠-葡萄糖协同转运蛋白2抑制剂等CKD治疗模式的转变显著改善了治疗效果,有利于筛查或病例筛查项目的成本效益分析。尽管如此,仍存在诸多障碍,包括资源分配、医疗保健资金、医疗基础设施,以及医疗专业人员和普通民众对肾脏疾病的认知。主要肾脏非政府组织通过协调努力,为各国政府优先安排肾脏健康议程,并使早期检测工作与其他现有项目保持一致,将实现效率最大化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f38/12233814/129737a78338/2175-8239-jbn-47-4-e20250106-gf01.jpg

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