Kim Jinseung, Lee Dong Ah, Lee Ho-Joon, Wi Jin-Hong, Park Kang Min
Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-ro 875, Haeundae-gu, Busan, 48108, Republic of Korea.
Sci Rep. 2025 Jul 7;15(1):24220. doi: 10.1038/s41598-025-09291-6.
This study aimed to investigate white matter microstructural changes in patients with cluster headaches using peak width of skeletonized mean diffusivity (PSMD) derived from diffusion tensor imaging (DTI). A total of 40 participants were recruited, comprising 20 patients with newly diagnosed cluster headaches and 20 healthy controls. DTI was conducted using a 3 Tesla MRI scanner. PSMD was quantified through a standardized multi-step process involving preprocessing, skeletonization, application of a custom mask, and histogram analysis performed with the FSL program. PSMD values were compared between the cluster headache group and the healthy controls, and correlation analyses were performed to examine association between PSMD and clinical factors. Patients with cluster headaches demonstrated significantly higher PSMD values than healthy controls (0.273 × 10 mm²/s vs. 0.227 × 10 mm²/s, p = 0.009). PSMD showed a positive correlation with age in the cluster headache group (r = 0.575, p = 0.008). However, there was no significant difference in PSMD between the hemisphere corresponding to the fisymptomatic side of the cluster headache and the contralateral hemisphere (0.270 × 10 mm²/s vs. 0.272 × 10 mm²/s, p = 0.909). This study demonstrates that patients with cluster headaches experience compromised white matter microstructural integrity, reflected by elevated PSMD values compared to healthy controls. The observed age-related increase in PSMD across both groups supports the role of aging in white matter microstructure. The lack of hemispheric differences in PSMD suggests that white matter alterations associated with cluster headaches are not confined to the symptomatic side, indicating a diffuse pattern of white matter involvement.
本研究旨在利用扩散张量成像（DTI）得出的骨架化平均扩散率峰值宽度（PSMD），研究丛集性头痛患者的白质微观结构变化。共招募了40名参与者，包括20名新诊断的丛集性头痛患者和20名健康对照者。使用3特斯拉磁共振成像扫描仪进行DTI检查。通过标准化的多步骤过程对PSMD进行量化，该过程包括预处理、骨架化、应用自定义掩码以及使用FSL程序进行直方图分析。比较了丛集性头痛组和健康对照组的PSMD值，并进行了相关性分析，以检验PSMD与临床因素之间的关联。丛集性头痛患者的PSMD值显著高于健康对照组（0.273×10平方毫米/秒对0.227×10平方毫米/秒，p = 0.009）。在丛集性头痛组中，PSMD与年龄呈正相关（r = 0.575，p = 0.008）。然而，丛集性头痛症状侧对应的半球与对侧半球之间的PSMD没有显著差异（0.270×10平方毫米/秒对0.272×10平方毫米/秒，p = 0.909）。本研究表明，与健康对照组相比，丛集性头痛患者的白质微观结构完整性受损，表现为PSMD值升高。两组中观察到的与年龄相关的PSMD增加支持了衰老在白质微观结构中的作用。PSMD缺乏半球差异表明，与丛集性头痛相关的白质改变并不局限于症状侧，表明白质受累呈弥漫性模式。
