Niu Siyuan, Yin Xiupeng, Cao Qinglei, Huang Kaiyu, Deng Zhongyuan, Cao Jie
College of Physical, Sungshin University, Seoul, Republic of Korea.
College of Science and Technology, Zhengzhou University, Zhengzhou, China.
Front Physiol. 2025 Jun 23;16:1614942. doi: 10.3389/fphys.2025.1614942. eCollection 2025.
Exercise-induced fatigue refers to a temporary decline in physiological function resulting from prolonged or high-intensity exercise, which is characterized by decreased muscle strength, diminished exercise performance, and heightened subjective feelings of fatigue. The study of exercise fatigue holds significant importance not only in competitive sports and public health, but also extends to medicine, military applications, and occupational safety. MicroRNA (miRNA) represents a class of non-coding RNA that plays a pivotal role in the regulation of gene expression. The involvement of miRNAs in exercise-induced fatigue has garnered increasing attention within the scientific community. This article provides an overview of fundamental concepts and biological functions associated with miRNAs, defines and classifies exercise fatigue while outlining its physiological changes, emphasizes alterations in miRNA expression during episodes of exercise-induced fatigue, and conducts an in-depth analysis regarding the mechanisms through which miRNAs influence this phenomenon via modulation of energy metabolism, inflammatory responses, and oxidative stress. Furthermore, this article anticipates future research directions as well as potential clinical applications for miRNAs concerning exercise-induced fatigue. This review holds significant importance for elucidating the molecular mechanisms underlying exercise-related fatigue while fostering advancements within sports medicine and rehabilitation science.
运动性疲劳是指长时间或高强度运动导致的生理功能暂时下降，其特征为肌肉力量减弱、运动表现降低以及主观疲劳感增强。运动疲劳的研究不仅在竞技体育和公共卫生领域具有重要意义，还延伸至医学、军事应用和职业安全等方面。微小RNA（miRNA）是一类在基因表达调控中起关键作用的非编码RNA。miRNA参与运动性疲劳已在科学界引起越来越多的关注。本文概述了与miRNA相关的基本概念和生物学功能，对运动疲劳进行了定义和分类并概述其生理变化，强调运动性疲劳发作期间miRNA表达的改变，并深入分析了miRNA通过调节能量代谢、炎症反应和氧化应激影响这一现象的机制。此外，本文还展望了miRNA在运动性疲劳方面未来的研究方向以及潜在的临床应用。这篇综述对于阐明运动相关疲劳的分子机制以及推动运动医学和康复科学的发展具有重要意义。
