Baek Seung Hak, Baek Suji, Kim Gyoungmin, Chi Andrew Sik, Kim Erin, Hwang Dong Hyeok, Ko Sarah, Jang Hyun Joo, Lee Kang Pa
Research & Development Center, UMUST R&D Corporation, Seoul, Republic of Korea.
Research and Development Center, UMUST R&D Corporation LA, Los Angeles, USA.
Phys Act Nutr. 2024 Jun;28(2):52-58. doi: 10.20463/pan.2024.0016. Epub 2024 Jun 30.
Epidemiological evidence shows that physical activity, including continuous stimulus changes and appropriate exercise programs, improves brain degeneration in the hippocampus, prefrontal cortex (PFC), and anterior cingulate cortex (ACC). Therefore, we investigated the possible synergistic effects of physical activity and nutrition in controlling chronic fatigue and reducing oxidative stress in patients at risk for depression and suicide.
We systematically reviewed the literature on various systemic factors related to the effects of 1) suppressing oxidative stress and 2) improving depression through exercise and nutrition. To conduct this review, we searched the PubMed database for papers published until May 1, 2024, using the terms "physical activity OR exercise" and "fatigue" OR "anti-fatigue," "oxidative stress" and "depression" and "suicide." We then reviewed the resulting list of articles related to antioxidant mechanisms.
Appropriate physical activity and natural product intake can substantially change whole-body homeostasis and provide a way to overcome the threat of depression and suicide by regulating metabolites, scavenging free radicals, and neurotransmitters.
Suicide and depression prevention play crucial roles in improving patients' quality of life. Our review provides evidence supporting the idea that exercise and antioxidant nutrition diminish oxidative stress and fatigue by improving the degeneration of the hippocampus, PFC, and ACC.
流行病学证据表明，体育活动，包括持续的刺激变化和适当的运动计划，可改善海马体、前额叶皮质（PFC）和前扣带回皮质（ACC）的脑退化。因此，我们研究了体育活动和营养在控制慢性疲劳以及降低有抑郁和自杀风险患者的氧化应激方面可能存在的协同作用。
我们系统回顾了有关各种全身因素的文献，这些因素与1）抑制氧化应激和2）通过运动及营养改善抑郁的效果相关。为进行此次综述，我们在PubMed数据库中搜索截至2024年5月1日发表的论文，使用的检索词为“体育活动或运动”以及“疲劳”或“抗疲劳”、“氧化应激”、“抑郁”和“自杀”。然后我们回顾了由此产生的与抗氧化机制相关的文章列表。
适当的体育活动和天然产物摄入可显著改变全身内环境稳态，并通过调节代谢物、清除自由基和神经递质提供一种克服抑郁和自杀威胁的方法。
预防自杀和抑郁在改善患者生活质量方面起着关键作用。我们的综述提供了证据支持这样一种观点，即运动和抗氧化营养通过改善海马体、PFC和ACC的退化来减轻氧化应激和疲劳。
