人多形核白细胞从亚溶细胞性补体攻击中的恢复是由细胞内游离钙的变化介导的。
The recovery of human polymorphonuclear leucocytes from sublytic complement attack is mediated by changes in intracellular free calcium.
作者信息
Morgan B P, Campbell A K
出版信息
Biochem J. 1985 Oct 1;231(1):205-8. doi: 10.1042/bj2310205.
Abstract
Using polymorphonuclear leucocyte-erythrocyte ghost hybrids entrapping the calcium-activated photoprotein obelin, we have demonstrated that sublytic amounts of the complement membrane attack complex induce a rapid but transient increase in intracellular free calcium ion concentration ([Ca2+]i). This increase in [Ca2+]i occurs prior to, and is required for, rapid removal of membrane attack complexes from the cell surface. The increase in [Ca2+]i is not only due to increased influx from outside the cell, but also results from mobilization of intracellular stores. The possible mechanism of mobilization of calcium, and the importance of an increase in [Ca2+]i as a mediator of recovery processes in nucleated cells, are discussed.
摘要
利用包裹钙激活光蛋白水母发光蛋白的多形核白细胞-红细胞幽灵杂种，我们已经证明，亚溶破量的补体膜攻击复合物会导致细胞内游离钙离子浓度（[Ca2+]i）迅速但短暂地升高。[Ca2+]i的这种升高发生在膜攻击复合物从细胞表面快速清除之前，并且是其必要条件。[Ca2+]i的升高不仅是由于细胞外流入增加，还源于细胞内储存的动员。文中讨论了钙动员的可能机制，以及[Ca2+]i升高作为有核细胞恢复过程介质的重要性。
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