Erkko Anni, Hero Matti, Varimo Tero, Raivio Taneli
Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Pediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.
J Pediatr Endocrinol Metab. 2025 Jul 10;38(9):880-886. doi: 10.1515/jpem-2024-0608. Print 2025 Sep 25.
In girls with precocious puberty (PP), adult height prediction (PAH) is crucial in treatment planning, yet the estimations may be prone to inaccuracies. This study aimed to compare the accuracy of two commonly used PAH methods in 6-8-year-old girls diagnosed with idiopathic GnRH-dependent PP.
This retrospective study included data on 60 six- to eight-year-old girls diagnosed with PP. Data was collected from medical records. Forty-eight (82 %) girls were treated with GnRH analogues, and 18 (30 %) had data on AH. Bone ages (BA) were assessed with Greulich-Pyle and BoneXpert. PAHs were estimated with Bayley-Pinneau and BoneXpert.
In girls treated with GnRH-analogue, AH did not significantly differ from the mean PAH calculated by Bayley-Pinneau (mean difference, -0.1 cm ± 6.6 cm (SD); p=0.93). Predicted adult height estimated by BoneXpert was higher than the actual AH (-3.6 cm ± 4.6 cm, p=0.01), but it showed lower variability in individual prediction errors and less bias related to the degree of BA advancement than Bayley-Pinneau. All subjects reached their mid-parental target height range.
In 6- to 8-year-old girls with signs of idiopathic GnRH-dependent precocious puberty, the potential to reach their growth target remains, and overestimation of residual height growth at diagnosis should be carefully considered before initiating treatment.
在性早熟（PP）女童中，预测成年身高（PAH）对治疗方案的制定至关重要，但这些估计可能容易出现不准确的情况。本研究旨在比较两种常用的PAH方法在诊断为特发性促性腺激素释放激素（GnRH）依赖性PP的6至8岁女童中的准确性。
这项回顾性研究纳入了60名诊断为PP的6至8岁女童的数据。数据从病历中收集。48名（82%）女童接受了GnRH类似物治疗，18名（30%）有成年身高（AH）数据。采用格鲁利希-派尔法和骨龄专家系统评估骨龄（BA）。用贝利-平诺法和骨龄专家系统估计PAH。
在接受GnRH类似物治疗的女童中，AH与贝利-平诺法计算的平均PAH无显著差异（平均差值为-0.1 cm±6.6 cm（标准差）；p=0.93）。骨龄专家系统预测的成年身高高于实际AH（-3.6 cm±4.6 cm，p=0.01），但与贝利-平诺法相比，其个体预测误差的变异性更低，与BA进展程度相关的偏差更小。所有受试者均达到了父母平均身高的目标范围。
在有特发性GnRH依赖性性早熟迹象的6至8岁女童中，仍有达到生长目标的潜力，在开始治疗前应仔细考虑诊断时对剩余身高增长的高估情况。
