Wirick Matthew J, Karp Xantha
Biochemistry, Cell and Molecular Biology, Central Michigan University, Mount Pleasant, Michigan, United States.
Biology, Central Michigan University, Mount Pleasant, Michigan, United States.
MicroPubl Biol. 2025 Jun 24;2025. doi: 10.17912/micropub.biology.001662. eCollection 2025.
In dauer larvae, the FOXO ortholog, , opposes the expression of the adult cell fate marker in the lateral hypodermis. acts in part via a heterochronic gene that promotes larval seam cell fate during non-dauer development. Here, we show that a different heterochronic gene, , does not function downstream of to regulate expression during dauer. A gain-of-function allele did not suppress ectopic expression in dauer larvae, and HBL-1 protein was not detectable in control or dauer larvae.
在滞育幼虫中，FOXO直系同源基因……在侧皮下组织中抑制成虫细胞命运标记物的表达。……部分通过一个异时性基因发挥作用，该基因在非滞育发育过程中促进幼虫接缝细胞命运。在这里，我们表明，另一个异时性基因……在滞育期间不作用于……下游来调节……的表达。一个功能获得性……等位基因不能抑制滞育幼虫中的异位……表达，并且在对照或滞育幼虫中检测不到HBL-1蛋白。
