Department of Nephrology, Qinghai Provincial People's Hospital, Xining, China.
Department of Nephrology, Xishui County People's Hospital Affiliated to Hubei University of Science and Technology, Huanggang, China.
Ren Fail. 2023;45(2):2283590. doi: 10.1080/0886022X.2023.2283590. Epub 2023 Nov 27.
: Diquat has replaced paraquat in agricultural areas as a herbicide but has led to extensive poisoning. Unlike paraquat, which targets the lungs, diquat primarily targets the kidneys. Autopsies and animal experiments suggest that interstitial kidney damage is the most critical renal lesion. Diquat is a nonselective chemical widely used for terrestrial and aquatic plants after the ban on paraquat. Although diquat is known to affect the kidneys mainly, no study has reported renal biopsy in patients with diquat poisoning.: We investigated the histopathologic feature in a young man with diquat poisoning who developed acute kidney injury by renal biopsy.: Autopsy and animal experiments suggest that interstitial kidney inflammation is the most critical renal lesion. Surprisingly, our results showed that lipid degeneration and acute tubular injury with limited interstitial inflammation were the dominant histologic findings in this patient. : Based on a renal biopsy, this was the first study describing the characteristics of the kidney affected by diquat poisoning. Our findings might provide information for managing patients who develop AKI due to diquat poisoning.
敌草快在农业领域已取代百草枯作为除草剂，但已导致广泛中毒。与靶向肺部的百草枯不同，敌草快主要靶向肾脏。尸检和动物实验表明，间质性肾损伤是最关键的肾病变。敌草快是一种非选择性化学物质，百草枯禁用后广泛用于陆地和水生植物。尽管已知敌草快主要影响肾脏，但尚无研究报告敌草快中毒患者的肾活检。我们通过肾活检研究了一名年轻男性敌草快中毒导致急性肾损伤的组织病理学特征。尸检和动物实验表明，间质性肾炎症是最关键的肾病变。令人惊讶的是，我们的结果显示，在该患者中，脂质变性和急性肾小管损伤伴有限的间质炎症是主要的组织学发现。基于肾活检，这是第一项描述敌草快中毒影响肾脏特征的研究。我们的发现可能为因敌草快中毒导致 AKI 的患者的治疗提供信息。
