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源自[具体来源1]和[具体来源2]的多功能碳点:合成、表征及生物医学应用

Multifunctional carbon dots from and : synthesis, characterization, and biomedical applications.

作者信息

Zhang Shengting, Tao Huili, Zheng Xiaodan, Zhao Sha, Wei Yunlin

机构信息

School of Ethnic Medicine, Yunnan Minzu University Kunming 650500 China.

Faculty of Life Science and Technology, Kunming University of Science and Technology Kunming 650500 China.

出版信息

RSC Adv. 2025 Jul 8;15(29):23845-23861. doi: 10.1039/d5ra03140k. eCollection 2025 Jul 4.

Abstract

Carbon dots (CDs) derived from (Pk-CDs) and (Ge-CDs) were synthesized a one-step hydrothermal method and characterized using TEM, XPS, and FTIR. Pk-CDs and Ge-CDs exhibited uniform spherical morphologies (6.2 ± 0.3 nm and 6.8 ± 0.4 nm, respectively) and excitation-dependent fluorescence. Antibacterial assays demonstrated potent inhibition against Gram-positive (, ) and Gram-negative bacteria (, ). antioxidant assays demonstrated that Pk-CDs outperformed Ge-CDs in DPPH radical and superoxide anion scavenging, with IC values of 2.994 mg mL and 0.30 mg mL, respectively. studies in a d-galactose-induced oxidative stress model confirmed significant improvements in SOD, GSH-Px, and MDA levels. These findings highlight the multifunctional properties of Pk-CDs and Ge-CDs, and underscore their potential as natural product-derived nanomaterials for biomedical applications, particularly as antibacterial and antioxidant agents.

摘要

通过一步水热法合成了源自(Pk - CDs)和(Ge - CDs)的碳点,并使用透射电子显微镜(TEM)、X射线光电子能谱(XPS)和傅里叶变换红外光谱(FTIR)对其进行了表征。Pk - CDs和Ge - CDs呈现出均匀的球形形态(分别为6.2±0.3纳米和6.8±0.4纳米)以及激发依赖性荧光。抗菌试验表明对革兰氏阳性菌(,)和革兰氏阴性菌(,)有强效抑制作用。抗氧化试验表明,Pk - CDs在清除DPPH自由基和超氧阴离子方面优于Ge - CDs,其IC值分别为2.994毫克/毫升和0.30毫克/毫升。在d - 半乳糖诱导的氧化应激模型中的研究证实,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH - Px)和丙二醛(MDA)水平有显著改善。这些发现突出了Pk - CDs和Ge - CDs的多功能特性,并强调了它们作为天然产物衍生的纳米材料在生物医学应用中的潜力,特别是作为抗菌和抗氧化剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93cb/12236301/60ab349199df/d5ra03140k-f1.jpg

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