外周组织肿瘤中乙酰乙酸辅酶A转移酶活性丧失。
Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues.
作者信息
Tisdale M J, Brennan R A
出版信息
Br J Cancer. 1983 Feb;47(2):293-7. doi: 10.1038/bjc.1983.38.
Abstract
The presence of succinyl-coenzyme A: acetoacetate CoA--transferase (3-oxo acid-CoA transferase), an initiator of ketone body utilization in non-hepatic tissue was examined in a number of animal and human tumours of peripheral tissues. While enzyme levels in heart, kidney, lymphocytes and bladder were high, the tumours contained low or non-detectable levels of transferase activity, comparable with that of normal liver. The activities of acetoacetyl-CoA thiolase paralleled that of the transferase, except for the high activity in liver, and in all cases the tumour content of the enzyme was lower than that of the brain. The activity of 3-hydroxybutyrate dehydrogenase was similar in both normal and tumour tissue. The results indicate that tumours of non-hepatic tissues may be unable to metabolize ketone-bodies and suggest a therapeutic strategy for selective starvation of the tumour by dietary modification.
摘要
在许多外周组织的动物和人类肿瘤中，检测了琥珀酰辅酶A：乙酰乙酸辅酶A转移酶（3-氧代酸-辅酶A转移酶）的存在，该酶是非肝组织中酮体利用的起始酶。虽然心脏、肾脏、淋巴细胞和膀胱中的酶水平较高，但肿瘤中转移酶活性水平较低或无法检测到，与正常肝脏相当。乙酰乙酰辅酶A硫解酶的活性与转移酶的活性平行，肝脏中的活性除外，在所有情况下，肿瘤中该酶的含量均低于大脑。3-羟基丁酸脱氢酶在正常组织和肿瘤组织中的活性相似。结果表明，非肝组织肿瘤可能无法代谢酮体，并提示通过饮食调整对肿瘤进行选择性饥饿的治疗策略。
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