Lin Yaoyao, Meng Lin, Guo Fanjia, Zhang Simei, Jiang Haiyan, Jin Mingjuan, Wang Jianbing, Tang Mengling, Chen Kun
Department of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Department of Public Health, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Aging Clin Exp Res. 2025 Jul 9;37(1):213. doi: 10.1007/s40520-025-03067-8.
Both insufficient and excessive essential trace elements (ETEs) intake can have adverse effects on health.
We aimed to evaluate the association between dietary intake and whole blood ETEs with frailty, and further explore the joint association of ETEs mixture.
The analyses included 4,009 participants for dietary intake and 2,635 for whole blood ETEs analyses. Frailty was assessed by FRAIL scale, while dietary intake ETEs were measured by a food frequency questionnaire, and whole blood ETEs were measured using inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). We used ordinal logistic regression and restricted cubic spline (RCS) models for individual association, and weighted quantile sum (WQS) regression and quantile g-computation for joint association.
Increased dietary intake chromium (Cr), manganese (Mn), copper (Cu), zinc (Zn), selenium (Se) and iron (Fe) were associated with a decreased likelihood of frailty. Blood Fe (Q4 versus Q1: OR = 0.76, 95% CI: 0.61, 0.95) was negatively associated with frailty. L-shaped dose-response associations were found for dietary intake ETEs with FRAIL score, while blood Mn had a U-shaped curve, and Fe showed a negatively linear trend. In the WQS analyses, both dietary intake (β = -0.076, 95% CI: -0.122, -0.030) and blood (β = -0.078, 95% CI: -0.136, -0.020) ETEs mixtures were associated with the FRAIL score. Quantile g-computation also showed similar results.
Our study suggests that different ETEs play distinct roles in frailty, and supplementation needs to consider the type of ETEs and appropriate dosage.
必需微量元素（ETEs）摄入不足和过量均会对健康产生不利影响。
我们旨在评估饮食摄入量和全血ETEs与衰弱之间的关联，并进一步探讨ETEs混合物的联合关联。
分析纳入了4009名参与者进行饮食摄入量分析，2635名参与者进行全血ETEs分析。采用衰弱量表评估衰弱情况，通过食物频率问卷测量饮食摄入的ETEs，使用电感耦合等离子体质谱法（ICP-MS）和电感耦合等离子体发射光谱法（ICP-OES）测量全血ETEs。我们使用有序逻辑回归和受限立方样条（RCS）模型分析个体关联，使用加权分位数和（WQS）回归和分位数g计算分析联合关联。
饮食中铬（Cr）、锰（Mn）、铜（Cu）、锌（Zn）、硒（Se）和铁（Fe）摄入量增加与衰弱可能性降低相关。血铁（Q4与Q1相比：OR = 0.76，95%CI：0.61，0.95）与衰弱呈负相关。饮食摄入ETEs与衰弱评分呈L形剂量反应关联，而血锰呈U形曲线，铁呈负线性趋势。在WQS分析中，饮食摄入（β = -0.076，95%CI：-0.122，-0.030）和血液（β = -0.078，95%CI：-0.136，-0.020）ETEs混合物均与衰弱评分相关。分位数g计算也显示了类似结果。
我们的研究表明，不同的ETEs在衰弱中发挥着不同作用，补充时需要考虑ETEs的类型和适当剂量。
