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分泌不止一类免疫球蛋白重链的小鼠浆细胞。IV. SAMM 368 IgG2b和IgA的κ链之间的序列差异。

Murine plasma cells secreting more than one class of immunoglobulin heavy chain. IV. Sequence differences between kappa-chains of SAMM 368 IgG2b and IgA.

作者信息

Morse H C, Goode J H, Rudikoff S

出版信息

J Immunol. 1977 Jul;119(1):361-3.

PMID:406326
Abstract

The amino terminal sequences of the kappa light chains from SAMM 368 IgG2b and IgA have been determined. The two chains belong to different kappa subgroups as indicated by 10 amino acid differences among the first 23 residues. An additional three residue differences were demonstrated in the sequence including the first complementarity region. These results indicate that single cells of SAMM 368 produce two unique kappa-chains.

摘要

已确定来自SMM 368 IgG2b和IgA的κ轻链的氨基末端序列。如前23个残基之间的10个氨基酸差异所示，这两条链属于不同的κ亚组。在包括第一个互补决定区的序列中还发现了另外三个残基差异。这些结果表明，SMM 368的单个细胞产生两条独特的κ链。

相似文献

1
Murine plasma cells secreting more than one class of immunoglobulin heavy chain. IV. Sequence differences between kappa-chains of SAMM 368 IgG2b and IgA.分泌不止一类免疫球蛋白重链的小鼠浆细胞。IV. SAMM 368 IgG2b和IgA的κ链之间的序列差异。
J Immunol. 1977 Jul;119(1):361-3.
2
Murine plasma cells secreting more than one class of immunoglobulin heavy chain. II. SAMM 368--a plasmacytoma secreting IgG2b-kappa and IgA-kappa immunoglobulins which do not share idiotypic determinants.分泌不止一类免疫球蛋白重链的小鼠浆细胞。II. SAMM 368——一种分泌IgG2b-κ和IgA-κ免疫球蛋白且不共享独特型决定簇的浆细胞瘤。
J Immunol. 1977 May;118(5):1682-9.
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Murine plasma cells secreting more than one class of immunoglobulin heavy chain. III. Immunoglobulin production by established cultures and cloned lines of SAMM 368.分泌不止一类免疫球蛋白重链的小鼠浆细胞。III. 已建立的SAMM 368培养物和克隆系的免疫球蛋白产生情况
J Immunol. 1977 Aug;119(2):457-64.
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Murine plasma cells secreting more than one class of immunoglobulin. VI. Secretion of completely assembled IgG2b and IgA molecules with segregated heavy chains and free light chains by spontaneous myeloma SAMM 368 in culture.分泌不止一类免疫球蛋白的小鼠浆细胞。VI. 培养中的自发性骨髓瘤SAMM 368分泌完全组装的IgG2b和IgA分子，其重链分离且轻链游离
J Immunol. 1979 May;122(5):1972-7.
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Murine plasma cells secreting more than one class of immunoglobulin. VII. Analysis of the IgG2B and IgA precursors within the cytoplasm of spontaneous myeloma SAMM 368 in culture shows segregation of heavy chains.分泌不止一类免疫球蛋白的小鼠浆细胞。VII. 对培养中的自发性骨髓瘤SAMM 368细胞质内IgG2B和IgA前体的分析显示重链的分离。
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Distribution and association of heavy and light chain variable region subgroups among human IgA immunoglobulins.人IgA免疫球蛋白中重链和轻链可变区亚组的分布及关联
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Three M-components IgA lambda + IgG kappa n + IgG kappa h in one patient (DA): lack of shared idiotypic determinants between IgA and IgG, and the presence of an unusual kappa h chain of 30,000 M.W.一名患者（DA）体内有三种M成分：IgA λ+、IgG κn+、IgG κh：IgA和IgG之间缺乏共同的独特型决定簇，且存在一条分子量为30,000的异常κh链。
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[A case with two M-components (IgG-kappa, IgA-kappa) (author's transl)].一例伴有两种M成分（IgG-κ、IgA-κ）的病例（作者译）
Rinsho Ketsueki. 1981 Oct;22(10):1552-7.
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Medical and technical usefulness of measurement of kappa and lambda immunoglobulin light chains in serum with an M-component.血清中κ和λ免疫球蛋白轻链与M蛋白成分检测的医学及技术应用价值
J Clin Chem Clin Biochem. 1989 Aug;27(8):519-23.
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[Immunonephelometric analysis of immunoglobulin light chains: agreement between the theoretical and experimental model. Assessment of the reference values of the kappa/lambda ratio and the heavy to light chain ratio].免疫球蛋白轻链的免疫比浊分析：理论模型与实验模型之间的一致性。κ/λ比值及重链与轻链比值参考值的评估
J Pharm Belg. 1996 Jan-Feb;51(1):23-27.

引用本文的文献

1
V kappa gene family in (Glu60 Ala30 Tyr10)n (GAT)-specific antibodies that express CGAT (or pGAT) public idiotypic specificities. Protein and mRNA sequencing of eight monoclonal V kappa chains.表达CGAT（或pGAT）公共独特型特异性的（Glu60 Ala30 Tyr10）n（GAT）特异性抗体中的Vκ基因家族。八条单克隆Vκ链的蛋白质和mRNA测序。
J Exp Med. 1983 Nov 1;158(5):1415-27. doi: 10.1084/jem.158.5.1415.