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分泌不止一类免疫球蛋白重链的小鼠浆细胞。II. SAMM 368——一种分泌IgG2b-κ和IgA-κ免疫球蛋白且不共享独特型决定簇的浆细胞瘤。

Murine plasma cells secreting more than one class of immunoglobulin heavy chain. II. SAMM 368--a plasmacytoma secreting IgG2b-kappa and IgA-kappa immunoglobulins which do not share idiotypic determinants.

作者信息

Morse H C, Neiders M E, Lieberman R, Lawton A R, Asofsky R

出版信息

J Immunol. 1977 May;118(5):1682-9.

PMID:67144
Abstract

SAMM 368 is a BALB/c plasmacytoma which secretes IgG2b-kappa and IgA-kappa paraproteins. Immunofluorescence studies of ascites cells from the tumor with purified, heavy chain class-specific antiglobulins demonstrate that single cells contain both IgG2 and IgA heavy chains. Idiotypic antisera prepared in mice and rabbits indicate that the two paraproteins produced by the tumor do not share idiotypic determinants. Analysis of the purified paraproteins for allotype markers showed that SAMM 368 IgA bears the BALB/c A12,13,14 determinants. SAMM 368 IgG2b does not carry any detectable allotypic determinants in spite of the fact that heterologous antisera identify the paraprotein as IgG2b.

摘要

SAMM 368是一种BALB/c浆细胞瘤，可分泌IgG2b-κ和IgA-κ副蛋白。用纯化的、重链类别特异性抗球蛋白对肿瘤腹水细胞进行免疫荧光研究表明，单个细胞同时含有IgG2和IgA重链。在小鼠和兔子中制备的独特型抗血清表明，肿瘤产生的两种副蛋白不共享独特型决定簇。对纯化的副蛋白进行同种异型标记分析表明，SAMM 368 IgA带有BALB/c A12、13、14决定簇。尽管异源抗血清将该副蛋白鉴定为IgG2b，但SAMM 368 IgG2b未携带任何可检测到的同种异型决定簇。

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引用本文的文献

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