Spencer S A, Small P G, Hull D
Br J Nutr. 1985 Mar;53(2):233-9. doi: 10.1079/bjn19850031.
Newborn rabbits were overfed by encouraging them to suck from two lactating does. These double-fed rabbits were compared with single-fed litter-mate controls. A standard set of fore- and hind-foot radiographs was obtained by taking daily radiographs from a normal litter and selecting the most representative film to act as a standard for that day. Bone age was assessed in single- and double-fed rabbits at ages 7, 14, and 21 d by comparing radiographs taken at these ages with the standard films. Double-feeding was associated with an increase in body-weight and an increase in bone age, although the former was increased to a much greater extent than the latter. The advance in bone age was proportional to an increase in bone length. There is little information available on overnutrition and skeletal maturation in man, but what information is available suggests that height and skeletal maturation are increased in parallel. The present study with rabbits supports the concept that overnutrition increases growth rate but does not disturb the relation between bone growth and bone age. Bone age can be assessed very sensitively in rabbits using the previously-described technique. It would therefore be a valuable technique for studying the endocrinology of skeletal maturation.
通过鼓励新生兔从两只泌乳母兔吸吮来使其过度喂养。将这些过度喂养的兔子与同窝单喂的对照兔子进行比较。通过每天从正常一窝兔子中拍摄X光片，并选择最具代表性的片子作为当天的标准片，从而获得一组标准的前足和后足X光片。通过将7日龄、14日龄和21日龄的单喂和双喂兔子所拍摄的X光片与标准片进行比较，来评估骨龄。过度喂养与体重增加和骨龄增加有关，尽管前者的增加程度比后者大得多。骨龄的提前与骨长度的增加成正比。关于人类营养过剩和骨骼成熟的信息很少，但现有的信息表明身高和骨骼成熟是平行增加的。目前对兔子的研究支持了这样一种观点，即营养过剩会提高生长速度，但不会扰乱骨骼生长与骨龄之间的关系。使用上述技术可以非常灵敏地评估兔子的骨龄。因此，这将是研究骨骼成熟内分泌学的一项有价值的技术。
