Choi Sung-Geun, Kim Seongchan, Kim Joon-Woo, Choi Myung-Kyun, Han Jieun, Koo Dong-Jun, Lee Soo-Hwan, Kim Aejin, Gu Ji-Woo, Kim Ki Hun, Lee Ju-Yong, Bae Jae-Young, Kim Sung-Yon, Kim Jeonghyun, Lee Hyojin, Kang Seung-Kyun
Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Biomaterials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Sci Adv. 2025 Jul 11;11(28):eads9269. doi: 10.1126/sciadv.ads9269. Epub 2025 Jul 9.
Drug localization, release control, and penetration into solid tissues through biological tight junctions are crucial for the treatment of localized diseases with biological barriers by maximizing therapeutic efficacy of the drug and minimizing damage to normal organs. Here, we introduce a dual-phoretic wireless drug delivery system that harnesses the physical control of ion transportation: electrophoresis for controllable release and iontophoresis for directional penetration. Adjustable, pulsatile, and repeatable drug release under biological conditions is achieved using ion diodes and Zn-based electrochemical cells. Through seamless integration with iontophoretic compartments, a fourfold improvement in delivery efficiency compared to drug diffusion, reaching the core of in vivo tumor, is verified by a 3D tomographic analysis. Fully implantable and wireless operation in a simulated 2-week therapeutic scenario results in a remarkable 50% tumor reduction from the initial volume while minimizing damage to nearby normal tissue and off-target organs such as the heart, liver, spleen, and kidney.
药物定位、释放控制以及通过生物紧密连接渗透到实体组织中，对于治疗具有生物屏障的局部疾病至关重要，这可以通过最大化药物的治疗效果并最小化对正常器官的损害来实现。在此，我们介绍一种双电泳无线药物递送系统，该系统利用离子运输的物理控制：电泳用于可控释放，离子电渗疗法用于定向渗透。使用离子二极管和锌基电化学电池可在生物条件下实现可调节、脉动式和可重复的药物释放。通过与离子电渗隔室无缝集成，与药物扩散相比，递送效率提高了四倍，能够到达体内肿瘤核心，这一点通过三维断层分析得到了验证。在模拟两周治疗方案中完全可植入且无线操作，可使肿瘤体积从初始体积显著减少50%，同时将对附近正常组织以及心脏、肝脏、脾脏和肾脏等非靶器官的损害降至最低。
