School of Materials Science and Engineering, The Key Laboratory of Advanced Materials of Ministry of Education, State Key Laboratory of New Ceramics and Fine Processing, , Center for Flexible Electronics Technology, Tsinghua University, Beijing 100084, China.
School of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, China.
ACS Nano. 2023 Mar 28;17(6):5727-5739. doi: 10.1021/acsnano.2c12125. Epub 2023 Mar 10.
Given the advantages of high energy density and easy deployment, biodegradable primary battery systems remain as a promising power source to achieve bioresorbable electronic medicine, eliminating secondary surgeries for device retrieval. However, currently available biobatteries are constrained by operational lifetime, biocompatibility, and biodegradability, limiting potential therapeutic outcomes as temporary implants. Herein, we propose a fully biodegradable primary zinc-molybdenum (Zn-Mo) battery with a prolonged functional lifetime of up to 19 days and desirable energy capacity and output voltage compared with reported primary Zn biobatteries. The Zn-Mo battery system is shown to have excellent biocompatibility and biodegradability and can significantly promote Schwann cell proliferation and the axonal growth of dorsal root ganglia. The biodegradable battery module with 4 Zn-Mo cells in series using gelatin electrolyte accomplishes electrochemical generation of signaling molecules (nitric oxide, NO) that can modulate the behavior of the cellular network, with efficacy comparable with that of conventional power sources. This work sheds light on materials strategies and fabrication schemes to develop high-performance biodegradable primary batteries to achieve a fully bioresorbable electronic platform for innovative medical treatments that could be beneficial for health care.
鉴于其高能量密度和易于部署的优势，可生物降解的原电池系统仍然是实现生物可吸收电子医学的有前途的电源，可避免因设备取出而进行二次手术。然而，目前可用的生物电池受到操作寿命、生物相容性和可生物降解性的限制，作为临时植入物限制了潜在的治疗效果。在此，我们提出了一种完全可生物降解的锌钼（Zn-Mo）原电池，其功能寿命延长至 19 天，与已报道的原锌生物电池相比，具有理想的能量容量和输出电压。Zn-Mo 电池系统表现出优异的生物相容性和可生物降解性，可显著促进雪旺细胞增殖和背根神经节的轴突生长。使用明胶电解质的 4 个 Zn-Mo 电池串联的可生物降解电池模块可实现信号分子（一氧化氮，NO）的电化学产生，从而调节细胞网络的行为，其功效可与传统电源相媲美。这项工作为开发高性能可生物降解原电池提供了材料策略和制造方案，以实现用于创新医疗的完全生物可吸收电子平台，这可能对医疗保健有益。
