Gupta R P, Verma P C, Gupta R K
Br J Nutr. 1985 Sep;54(2):421-8. doi: 10.1079/bjn19850127.
Thirty-three male, weanling guinea-pigs were divided into two groups. One group was fed on a zinc-deficient (ZnD) diet (1.25 mg Zn/kg diet) for 45 d and then divided into two subgroups: subgroup 1 continued on diet ZnD while subgroup 2 was fed on a Zn-repleted diet (100 mg Zn/kg diet) for 15 d. The second group was fed on a Zn-adequate diet (50 mg Zn/kg diet) for 60 d. Zn deficiency could be produced within 21 d as evidenced by clinical signs and reduction in serum Zn concentration. Clinical signs exhibited were listlessness, scabby lesions on skin near the foot pads, mild alopecia and a reduction in body-weight gain. No effect was observed on food intake. Significant decreases in packed cell volume and total leucocyte count from 48 d onwards accompanied by absolute lymphocytopenia and relative neutrophilia were observed. Supplementation of Zn in the Zn-repleted group resulted in marked, through incomplete, improvement with regard to serum Zn concentration, clinical signs and haematological changes.
33只雄性断奶豚鼠被分为两组。一组喂食低锌（ZnD）日粮（每千克日粮含锌1.25毫克）45天，然后再分为两个亚组：亚组1继续喂食低锌日粮，而亚组2喂食补锌日粮（每千克日粮含锌100毫克）15天。第二组喂食锌充足日粮（每千克日粮含锌50毫克）60天。临床症状和血清锌浓度降低表明，21天内即可出现锌缺乏。出现的临床症状有精神萎靡、脚垫附近皮肤结痂、轻度脱毛以及体重增加减少。未观察到对食物摄入量有影响。从48天起，观察到红细胞压积和白细胞总数显著下降，同时伴有绝对淋巴细胞减少和相对中性粒细胞增多。补锌组补充锌后，血清锌浓度、临床症状和血液学变化均有明显但不完全的改善。
