Zandbergen K, Rousian M, Griep Q C J, Koning A H J, Cornette J M J, Rebel B R, Steegers E A P, Mulders A G M G J
Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Department of Pathology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Prenat Diagn. 2025 Aug;45(9):1130-1138. doi: 10.1002/pd.6846. Epub 2025 Jul 9.
To study the feasibility and reproducibility of two ultrasound (US) related post-processing methods for first-trimester fetal cardiac function assessment by ventricle volume measurements.
First-trimester transvaginal Spatio-Temporal Image Correlation (STIC) US datasets acquired between 11-13 weeks gestational age (GA) were used to perform fetal cardiac ventricle volume (FCVV) measurements in the end-diastolic (EDVV) and end-systolic (ESVV) phases using two methods: the manual segmentation method Virtual Organ Computed-Aided AnaLysis (VOCAL) and (semi-)automated volume measuring method Virtual Reality (VR). Reproducibility was assessed by calculating the intra-, interobserver and intersystem agreement using intraclass correlation coefficients (ICCs) followed by Bland-Altman plots.
25 STIC US datasets were selected. The mean GA was 13 weeks (SD 2.3 days) and mean crown-rump length was 68.0 mm (range 61.0-75.6 mm). The intra- and inter-observer agreement for both methods resulted in good to excellent agreement (ICCs > 0.85). Mean relative differences for all FCVV measurements were < 10.0%, except for the inter-observer agreement of the VOCAL ESVV measurement (40.6%). The inter-system agreement showed poor to moderate agreement (ICCs 0.32-0.75) and moderate to good agreement (ICCs 0.62-0.78) in terms of absolute agreement and consistency, respectively.
FCVV measurements performed in STIC US datasets using VR are feasible and reproducible, specifically when compared to VOCAL.
通过心室容积测量研究两种超声（US）相关后处理方法用于孕早期胎儿心功能评估的可行性和可重复性。
使用孕龄（GA）在11 - 13周之间获取的孕早期经阴道时空图像相关（STIC）超声数据集，采用两种方法在舒张末期（EDVV）和收缩末期（ESVV）阶段测量胎儿心室容积（FCVV）：手动分割方法虚拟器官计算机辅助分析（VOCAL）和（半）自动容积测量方法虚拟现实（VR）。通过使用组内相关系数（ICC）计算观察者内、观察者间和系统间一致性，随后绘制布兰德 - 奥特曼图来评估可重复性。
选择了25个STIC超声数据集。平均孕龄为13周（标准差2.3天），平均头臀长度为68.0毫米（范围61.0 - 75.6毫米）。两种方法的观察者内和观察者间一致性均为良好至优秀（ICC > 0.85）。除了VOCAL ESVV测量的观察者间一致性（40.6%）外，所有FCVV测量的平均相对差异均< 10.0%。系统间一致性在绝对一致性方面显示为差至中等一致性（ICC 0.32 - 0.75），在一致性方面显示为中等至良好一致性（ICC 0.62 - 0.78）。
使用VR在STIC超声数据集中进行FCVV测量是可行且可重复的，特别是与VOCAL相比。
