Chiku Yoshiaki, Hirano Takao, Ito Shun, Akahane Keita, Murata Toshinori
Department of Ophthalmology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Sci Rep. 2025 Jul 9;15(1):24695. doi: 10.1038/s41598-025-08340-4.
To evaluate the effectiveness of the non-mydriatic mode of the HE-2000 electroretinogram (ERG) by comparing photopic ERGs of non-mydriatic versus dilated eyes. This retrospective study included patients with grade 2 cataracts between January and July 2022. Photopic ERGs were recorded using the HE-2000 system in mydriatic eyes with a 3 cd·s/m flashing stimulus and in non-mydriatic eyes using the non-mydriatic mode with a 10 cd·s/m stimulus. Amplitudes and implicit times of the a-wave, b-wave, and flicker ERG were compared using the Wilcoxon signed-rank test. Correlations between these parameters were analyzed using Spearman's rank correlation coefficient. In 54 eyes of 27 participants, the b-wave and flicker ERG amplitudes were lower in non-dilated eyes compared to dilated ones, with prolonged implicit times observed in non-dilated eyes (p < 0.0001). Despite these differences, both b-wave and flicker ERG amplitudes and implicit times showed strong correlations between dilated and non-dilated eyes (p < 0.01). However, the a-wave amplitude was more variable and less consistently measurable in non-dilated eyes. The HE-2000 system can provide clinically useful ERG recordings in non-dilated eyes, particularly for b-wave and flicker responses. Further validation under non-mydriatic conditions is required to establish its broader clinical utility.
通过比较散瞳与未散瞳眼的明视视网膜电图（ERG），评估HE-2000视网膜电图仪的非散瞳模式的有效性。这项回顾性研究纳入了2022年1月至7月间患有2级白内障的患者。使用HE-2000系统在散瞳眼以3 cd·s/m闪光刺激记录明视ERG，并在未散瞳眼使用非散瞳模式以10 cd·s/m刺激记录。使用Wilcoxon符号秩检验比较a波、b波和闪光ERG的振幅和隐含时间。使用Spearman等级相关系数分析这些参数之间的相关性。在27名参与者的54只眼中，未散瞳眼的b波和闪光ERG振幅低于散瞳眼，未散瞳眼观察到隐含时间延长（p < 0.0001）。尽管存在这些差异，b波和闪光ERG的振幅和隐含时间在散瞳和未散瞳眼之间均显示出强相关性（p < 0.01）。然而，未散瞳眼中a波振幅变化更大且测量一致性更低。HE-2000系统可以在未散瞳眼中提供具有临床意义的ERG记录，特别是对于b波和闪光反应。需要在非散瞳条件下进行进一步验证以确立其更广泛的临床应用价值。
