Léglise D, Abgrall J F, Desfontaine B, Dutel J L, Bardou L G, Brière J
Biomed Pharmacother. 1985;39(3):135-9.
Lipoproteins have previously, been studied in various myeloproliferative disorders. This study focused only on agnogenic myeloid metaplasia (AMM). Total cholesterol (TC), phospholipids (PL) and triglycerides (TG) were measured not only in serum but also in HDL, VLDL and LDL with in the same time total apolipoproteins A1 and B. Besides hypocholesterolemia (p less than 0.01) HDL-TC were significantly diminished in mmol/l (p less than 0.01) and in percentage (p less than 0.01) while LDL.TC was decreased in mmol/l (p less than 0.01). The whole lipid moity (TC + PL + TG) of VLDL was increased (p less than 0.05). Cardiovascular diseases occur frequently in these hypocholesterolemic patients. Atherogenic ratios: LDL.TC on HDL.TC or VLDL.TC + LDL.TC on HDL.TC were not significantly higher than matching age and sex controls. Atherogenic risks could be partly related to the significant decrease of HDL.TC.
此前已对各种骨髓增殖性疾病中的脂蛋白进行了研究。本研究仅聚焦于原发性骨髓化生（AMM）。不仅测定了血清中的总胆固醇（TC）、磷脂（PL）和甘油三酯（TG），还同时测定了高密度脂蛋白（HDL）、极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）中的这些指标以及总载脂蛋白A1和B。除了低胆固醇血症（p<0.01）外，HDL-TC在毫摩尔/升（p<0.01）和百分比方面（p<0.01）均显著降低，而LDL-TC在毫摩尔/升方面降低（p<0.01）。VLDL的总脂质部分（TC + PL + TG）增加（p<0.05）。这些低胆固醇血症患者经常发生心血管疾病。致动脉粥样硬化比率：LDL-TC与HDL-TC之比或VLDL-TC + LDL-TC与HDL-TC之比并不显著高于匹配的年龄和性别对照组。致动脉粥样硬化风险可能部分与HDL-TC的显著降低有关。
