Kiss A, Telek B, Rák K
Debreceni Orvostudományi Egyetem II. Belgyógyászati Klinika.
Orv Hetil. 1994 Nov 27;135(48):2643-6.
In the recent years more and more data suggest a significant relationship between malignant diseases and cholesterol, respectively lipoprotein metabolism. It is a significant decrease of cholesterol in primary myelofibrosis (agnogenic myeloid metaplasia) and in secondary myelofibrosis. Similarly, the HDL and LDL cholesterol levels are also decreased in these diseases. On the contrary, the triglyceride level is significantly higher in these groups, 41 patients with agnogenic myeloid metaplasia and 16 patients with myelofibrosis following polycythaemia vera were examined. Decrease of serum cholesterol level was significant: 3.7 and 3.3 mmol/l and 5.2 mmol/l in 76 healthy controls, as the mean values.
近年来，越来越多的数据表明恶性疾病与胆固醇及脂蛋白代谢之间存在显著关系。在原发性骨髓纤维化（原发性骨髓化生）和继发性骨髓纤维化中，胆固醇显著降低。同样，这些疾病中的高密度脂蛋白和低密度脂蛋白胆固醇水平也降低。相反，在这些组中甘油三酯水平显著更高，对41例原发性骨髓化生患者和16例真性红细胞增多症后骨髓纤维化患者进行了检查。血清胆固醇水平的降低很显著：76名健康对照者的平均值分别为3.7 mmol/l、3.3 mmol/l和5.2 mmol/l。
