Bogdanov K Iu, Zakharov S I, Belousov V V, Rozenshtraukh L V
Biull Eksp Biol Med. 1985 Nov;100(11):566-8.
The effects of caffeine (0.5-12 mM) and cooling on the mechanical noise (MN) and relaxation rate of contractile response (RR) were studied in experiments on rat papillary muscles. Mean frequency of MN and RR were found to have similar temperature dependences from 12 to 32 degrees C. MN amplitude was more sensitive to the action of sarcoplasmic reticulum activity blocker, caffeine, than RR one. MN as an index of sarcoplasmic reticulum activity made it possible to demonstrate a competition between caffeine and local anaesthetics described earlier for skeletal muscles.
在大鼠乳头肌实验中，研究了咖啡因（0.5 - 12 mM）和降温对机械性噪声（MN）及收缩反应松弛率（RR）的影响。发现MN和RR的平均频率在12至32摄氏度范围内具有相似的温度依赖性。MN幅度比RR幅度对肌浆网活性阻滞剂咖啡因的作用更敏感。MN作为肌浆网活性指标，使得有可能证明咖啡因与先前所述的骨骼肌局部麻醉药之间存在竞争关系。
