Kim Sang Hyuk, Zo Sungmin, Kong Sung A, Cho Ju Hee, Do Jong Geol, Shin Sun Hye, Park Hye Yun
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju, Republic of Korea.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Int J Chron Obstruct Pulmon Dis. 2025 Jul 4;20:2199-2210. doi: 10.2147/COPD.S510974. eCollection 2025.
A higher prevalence of sarcopenia has been demonstrated in individuals with airflow limitation (AFL). However, data on the impact of sarcopenia on quality of life, utilization of healthcare, and mental health in individuals with AFL are limited.
We used data from the 2014-2019 Korea National Health and Nutrition Examination Survey (KNHANES), and participants with AFL were included. Sarcopenia was assessed using hand grip strength (HGS). The outcomes were health-related quality of life (HRQoL), utilization of healthcare, and mental health. The impact of low HGS and outcomes was assessed using multivariable logistic regression analysis.
Among participants with AFL, 12.6% had low HGS and the median (interquartile range) of HGS was 22.5 (18.9-26.1) kg for women and 37.7 (32.9-42.6) kg for men. After adjusting for confounders, low HGS was associated with a decrease in HRQoL (usual activities: adjusted odds ratio [aOR], 1.70; 95% confidence interval [CI], 1.14-2.54; pain/discomfort: aOR, 1.44; 95% CI, 1.02-2.02, anxiety/depression: aOR, 1.59; 95% CI, 1.05-2.41), and increased perceived stress (aOR, 1.77; 95% CI, 1.24-2.53). In the subgroup analysis, the impact of low HGS on HRQoL, utilization of healthcare, and mental health was more evident in the reduced lung function and inactive physical activity groups.
Overall, low HGS was associated with decreased quality of life and worsening mental health in participants with AFL. Our findings underscore the importance of muscle strength for HRQoL, particularly in those with impaired lung function and sedentary lifestyles, suggesting that regular physical activity including muscle-strengthening exercises may improve HRQoL.
气流受限（AFL）个体中肌肉减少症的患病率较高。然而，关于肌肉减少症对AFL个体生活质量、医疗保健利用和心理健康影响的数据有限。
我们使用了2014 - 2019年韩国国家健康与营养检查调查（KNHANES）的数据，纳入了AFL参与者。使用握力（HGS）评估肌肉减少症。结局指标为健康相关生活质量（HRQoL）、医疗保健利用和心理健康。使用多变量逻辑回归分析评估低HGS与结局之间的影响。
在AFL参与者中，12.6%的人HGS较低，女性HGS的中位数（四分位间距）为22.5（18.9 - 26.1）千克，男性为37.7（32.9 - 42.6）千克。在调整混杂因素后，低HGS与HRQoL下降相关（日常活动：调整后的优势比[aOR]，1.70；95%置信区间[CI]，1.14 - 2.54；疼痛/不适：aOR，1.44；95%CI，1.02 - 2.02，焦虑/抑郁：aOR，1.59；95%CI，1.05 - 2.41），且感知压力增加（aOR，1.77；95%CI，1.24 - 2.53）。在亚组分析中，低HGS对HRQoL、医疗保健利用和心理健康的影响在肺功能降低和身体活动不活跃的组中更为明显。
总体而言，低HGS与AFL参与者生活质量下降和心理健康恶化相关。我们的研究结果强调了肌肉力量对HRQoL的重要性，特别是在肺功能受损和久坐生活方式的人群中，这表明包括肌肉强化运动在内的定期体育活动可能改善HRQoL。
