Hashimoto Takehiro, Hioki Yoshihide, Komiya Kosaku, Hiramatsu Kazufumi
Infection Control, Oita University Hospital, Yufu, JPN.
Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, JPN.
Cureus. 2025 Jun 8;17(6):e85579. doi: 10.7759/cureus.85579. eCollection 2025 Jun.
We report a rare case of a mycotic aneurysm caused by , undetectable by Gram staining or surgical specimen culture obtained after 10 days of antimicrobial therapy. However, the pathogen was successfully detected by 16S rRNA gene sequencing. An 83-year-old woman with comorbid hypertension presented with lumbar and lateral abdominal pain and was diagnosed with an abdominal mycotic aneurysm. Despite its low sensitivity for a negative Gram staining test and culture-negative specimens, 16S rRNA gene sequencing can identify the causative organism and facilitate appropriate antibiotic therapy.
我们报告了一例罕见的霉菌性动脉瘤病例，该病例由[未提及具体病因]引起，在抗菌治疗10天后进行的革兰氏染色或手术标本培养均未检测到病原体。然而，通过16S rRNA基因测序成功检测到了病原体。一名患有高血压合并症的83岁女性出现腰腹部疼痛，被诊断为腹部霉菌性动脉瘤。尽管革兰氏染色阴性试验和培养阴性标本的敏感性较低，但16S rRNA基因测序可以识别致病微生物并有助于进行适当的抗生素治疗。
