van der Zee J, van Rhoon G C, Wike-Hooley J L, Reinhold H S
Br J Radiol. 1985 Mar;58(687):243-50. doi: 10.1259/0007-1285-58-687-243.
A group of 36 patients, treated on 44 fields with fractionated treatments of local high-frequency induced hyperthermia and radiotherapy to the low total dose of 14-25 Gy, was retrospectively evaluated for differences between responders (i.e., complete and partial responders) and non-responders. A response rate of 86% was achieved, comprising 14% (6/44) complete and 73% (32/44) partial response. There was an indication that the probability of complete response is greater in smaller tumours. The tumour temperatures achieved were higher in the responders than in the non-responders. Logistic analysis was performed on the mean temperature achieved. This temperature parameter yielded a significant positive dose-effect relationship with regard to therapeutic effect, from which a 50% effective dose of 38.8 degrees C was calculated. The data indicate that to obtain the maximum therapeutic effect, i.e., greater than 95% response rate, tumour temperatures above 42.5 degrees C need to be achieved.
一组36例患者接受了44个野的局部高频感应热疗与低总剂量14 - 25 Gy的放疗分割治疗，对反应者（即完全缓解和部分缓解者）与无反应者之间的差异进行了回顾性评估。实现了86%的缓解率，包括14%（6/44）的完全缓解和73%（32/44）的部分缓解。有迹象表明，较小肿瘤的完全缓解概率更高。反应者达到的肿瘤温度高于无反应者。对达到的平均温度进行了逻辑分析。该温度参数在治疗效果方面产生了显著的正剂量效应关系，据此计算出50%有效剂量为38.8摄氏度。数据表明，为了获得最大治疗效果，即缓解率大于95%，需要使肿瘤温度达到42.5摄氏度以上。
