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一名中东男性的神经白塞病:罕见且具有挑战性的诊断

Neuro-Behçet's Disease in a Middle Eastern Male: A Rare and Challenging Diagnosis.

作者信息

Mahmood Madeena, Iqbal Saqib, Badawi Abbas

机构信息

Hospital Medicine, Mersey West Lancashire Teaching Hospitals NHS Trust, Liverpool, GBR.

Respiratory Medicine, Mersey West Lancashire Teaching Hospitals NHS Trust, Liverpool, GBR.

出版信息

Cureus. 2025 Jun 9;17(6):e85628. doi: 10.7759/cureus.85628. eCollection 2025 Jun.

DOI:10.7759/cureus.85628
PMID:40636664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12240449/
Abstract

Neuro-Behçet's Disease (NBD) is a rare neurological complication of a chronic, multisystem inflammatory condition. It typically manifests several years after the onset of initial non-neurological symptoms, such as oral and genital ulcers, uveitis, and dermatological or gastrointestinal issues. Neurological involvement occurs infrequently and can be challenging to diagnose in its early stages. This case describes a young adult who presented with progressive neurological symptoms, following a long-standing history of systemic inflammatory features. The diagnostic process included neuroimaging that revealed signs consistent with intracranial abnormalities and vascular involvement. Following clinical and radiological assessment, a diagnosis of NBD was made, and appropriate treatment was initiated. This case underscores the importance of considering a broad differential diagnosis when evaluating patients with complex symptom profiles, and the value of a comprehensive, patient-centred approach to avoid unnecessary investigations and reduce the length of hospital stay.

摘要

神经白塞病(NBD)是一种慢性多系统炎症性疾病的罕见神经并发症。它通常在最初的非神经症状出现数年之后才表现出来,如口腔溃疡、生殖器溃疡、葡萄膜炎以及皮肤或胃肠道问题。神经系统受累情况并不常见,且在早期阶段诊断具有挑战性。本病例描述了一名年轻成年人,在长期存在全身炎症特征后出现进行性神经症状。诊断过程包括神经影像学检查,结果显示与颅内异常和血管受累相符的体征。经过临床和放射学评估后,确诊为神经白塞病,并开始了适当的治疗。该病例强调了在评估具有复杂症状的患者时考虑广泛鉴别诊断的重要性,以及采用全面、以患者为中心的方法以避免不必要检查并缩短住院时间的价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/b20891374753/cureus-0017-00000085628-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/7a9b837aebb0/cureus-0017-00000085628-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/c105a52b3af9/cureus-0017-00000085628-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/c00f449d859a/cureus-0017-00000085628-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/b20891374753/cureus-0017-00000085628-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/7a9b837aebb0/cureus-0017-00000085628-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/c105a52b3af9/cureus-0017-00000085628-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/c00f449d859a/cureus-0017-00000085628-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f2e/12240449/b20891374753/cureus-0017-00000085628-i04.jpg

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本文引用的文献

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Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review.白塞病:发病机制、临床特征及治疗方法的全面综述
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