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在肾绞痛的治疗中使用抗毒蕈碱药物有合理的理由吗?

Are there valid reasons for using anti-muscarinic drugs in the management of renal colic?

作者信息

Tomiak R H, Barlow R B, Smith P J

出版信息

Br J Urol. 1985 Oct;57(5):498-9. doi: 10.1111/j.1464-410x.1985.tb05854.x.

DOI:10.1111/j.1464-410x.1985.tb05854.x
PMID:4063728
Abstract

Experiments have been carried out with isolated ring preparations of human ureter. The tissue displayed spontaneous activity and contracted when exposed to barium chloride (0.5-4 mM) but no responses were obtained with carbachol (0.1 micromolar-0.1 mM). This raises questions about the value of treating ureteric colic with anti-muscarinic drugs.

摘要

已经对人体输尿管的离体环状标本进行了实验。该组织表现出自发活动,并且在暴露于氯化钡(0.5 - 4 mM)时会收缩,但使用卡巴胆碱(0.1微摩尔 - 0.1 mM)时未获得反应。这引发了关于用抗毒蕈碱药物治疗输尿管绞痛的价值的疑问。

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