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合子基因组激活核心处的外周染色质重塑

Peripheral chromatin remodeling at the center of zygotic genome activation.

作者信息

de Chancel Laure, Maître Jean-Léon

机构信息

Institut Curie, Université PSL, CNRS UMR3215, INSERM U934, Paris, France.

Institut Curie, Université PSL, CNRS UMR3215, INSERM U934, Paris, France.

出版信息

Cell Genom. 2025 Jul 9;5(7):100922. doi: 10.1016/j.xgen.2025.100922.

DOI:10.1016/j.xgen.2025.100922
PMID:40639342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12278610/
Abstract

Pal and colleagues investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable during the very early steps of mouse development when they can be rescued at the 2-cell stage.

摘要

帕尔及其同事研究了小鼠植入前胚胎中LAD建立的分子调控机制。这项研究为LAD的生理重塑提供了见解，揭示了合子LAD在小鼠发育的早期阶段实际上可能是可有可无的，因为它们在二细胞阶段可以被挽救。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d3/12278610/980ebc293dee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d3/12278610/980ebc293dee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d3/12278610/980ebc293dee/gr1.jpg

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本文引用的文献

1
The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways.小鼠胚胎中核组织的建立是由多种表观遗传途径精心安排的。
Cell. 2025 Jun 26;188(13):3583-3602.e21. doi: 10.1016/j.cell.2025.03.044. Epub 2025 Apr 23.
2
Epigenome dynamics in early mammalian embryogenesis.早期哺乳动物胚胎发生过程中的表观基因组动态变化
Nat Rev Genet. 2025 Apr 3. doi: 10.1038/s41576-025-00831-4.
3
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint.染色体错分离通过机械敏感的核膜检查点触发细胞周期停滞。
Nat Cell Biol. 2025 Jan;27(1):73-86. doi: 10.1038/s41556-024-01565-x. Epub 2025 Jan 8.
4
Antagonism between H3K27me3 and genome-lamina association drives atypical spatial genome organization in the totipotent embryo.H3K27me3 与基因组-核膜关联之间的拮抗作用驱动全能胚胎中非常规的空间基因组组织。
Nat Genet. 2024 Oct;56(10):2228-2237. doi: 10.1038/s41588-024-01902-8. Epub 2024 Sep 16.
5
Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity.早期小鼠胚胎中层粘连相关域的重组织受 RNA 聚合酶 II 活性的调节。
Genes Dev. 2023 Oct 1;37(19-20):901-912. doi: 10.1101/gad.350799.123. Epub 2023 Nov 1.
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Identification of epigenetic modulators as determinants of nuclear size and shape.鉴定表观遗传调节剂作为核大小和形状的决定因素。
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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.异染色质驱动的核软化可保护基因组免受机械应激诱导的损伤。
Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052. Epub 2020 Apr 16.
8
Genomic insights into chromatin reprogramming to totipotency in embryos.胚胎中染色质重编程至全能性的基因组学见解。
J Cell Biol. 2019 Jan 7;218(1):70-82. doi: 10.1083/jcb.201807044. Epub 2018 Sep 26.
9
A Method for the Acute and Rapid Degradation of Endogenous Proteins.一种内源性蛋白质急性快速降解的方法。
Cell. 2017 Dec 14;171(7):1692-1706.e18. doi: 10.1016/j.cell.2017.10.033. Epub 2017 Nov 16.
10
Building up the nucleus: nuclear organization in the establishment of totipotency and pluripotency during mammalian development.构建细胞核：哺乳动物发育过程中全能性和多能性建立过程中的核组织
Genes Dev. 2016 Mar 15;30(6):611-21. doi: 10.1101/gad.273805.115.