Ramalingam K, Thyvelikakath G X, Berlin K D, Chesnut R W, Brown R A, Durham N N, Ealick S E, van der Helm D
J Med Chem. 1977 Jun;20(6):847-50. doi: 10.1021/jm00216a024.
A small series of pyrazoles and isoxazoles derived from thiochroman-4-one has been synthesized and characterized. The compounds were examined for their in vitro inhibitory activity against Bacillus subtilis and Pseudomonas fluorescens. Among the tested compounds the pyrazole derivative from thiochroman-4-one was found to be the most effective inhibitor of growth of B. subtilis. Extensive H NMR analysis was recorded for all compounds.
已合成并表征了一系列源自硫代色满-4-酮的吡唑和异恶唑。对这些化合物进行了体外抗枯草芽孢杆菌和荧光假单胞菌的抑制活性检测。在测试的化合物中，硫代色满-4-酮的吡唑衍生物被发现是枯草芽孢杆菌生长的最有效抑制剂。对所有化合物进行了广泛的核磁共振氢谱分析。
