Qu Fei, Zhao Qingqing, Jin Yi
Department of Pathology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, P.R. China.
Metabolism and Disease Research Centre, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, P.R. China.
Int J Mol Med. 2025 Sep;56(3). doi: 10.3892/ijmm.2025.5578. Epub 2025 Jul 11.
Histone deacetylase 6 (HDAC6), a distinctive member of the histone deacetylase family, plays a crucial role in regulating the cellular response to oxidative stress. Unlike other HDACs, HDAC6 primarily deacetylates non‑histone proteins, influencing various cellular functions critical to the pathogenesis of numerous oxidative stress‑related diseases. This review summarizes the latest research on how HDAC6 affects oxidative stress pathways and its impact on diseases such as neurodegeneration, cancer and cardiovascular disorders. Additionally, the therapeutic potential of targeting HDAC6, as evidenced by preclinical trials, was discussed, suggesting that HDAC6 inhibitors can ameliorate symptoms and alter disease progression in numerous disease models. By elucidating the multifaceted roles of HDAC6 in oxidative stress and disease, the review aims to underscore its potential as a therapeutic target. This review enhances the understanding of HDAC6 and presents new opportunities for innovative treatment approaches that can address oxidative stress‑related illnesses.
组蛋白去乙酰化酶6（HDAC6）是组蛋白去乙酰化酶家族的一个独特成员，在调节细胞对氧化应激的反应中起关键作用。与其他HDAC不同，HDAC6主要使非组蛋白去乙酰化，影响对多种氧化应激相关疾病发病机制至关重要的各种细胞功能。本综述总结了关于HDAC6如何影响氧化应激途径及其对神经退行性疾病、癌症和心血管疾病等疾病影响的最新研究。此外，还讨论了临床前试验证明的靶向HDAC6的治疗潜力，表明HDAC6抑制剂可改善多种疾病模型中的症状并改变疾病进展。通过阐明HDAC6在氧化应激和疾病中的多方面作用，本综述旨在强调其作为治疗靶点的潜力。本综述增进了对HDAC6的理解，并为解决氧化应激相关疾病的创新治疗方法带来了新机会。
