Priyono Drajad, Yerizel Eti, Harun Harnavi, Suharti Netti
Biomedical Department, Faculty of Medicine, Andalas University - M. Djamil Hospital, Padang, Indonesia..
Acta Med Indones. 2025 Apr;57(2):228-236.
Chronic kidney disease (CKD) is a global health problem with increasing prevalence. This study aims to analyze the effect of Ramadan fasting on important biomarkers in CKD patients.
A prospective cohort study was conducted on 30 CKD patients with stages 1, 2, and 3A who underwent Ramadan fasting. Measurements of MDA, PARP, SIRT1, NR1D1, and TGF-β levels were carried out before fasting, 2 weeks during fasting, and after fasting using the Enzyme-linked immunosorbent assay (ELISA) method.
There were significant decreases in urea, fasting blood glucose, HbA1C, and uric acid levels (p<0.05). MDA and SIRT1 decreased significantly (p<0.001), while PARP and NR1D1 increased significantly (p<0.001). TGF-β also showed a decrease. There were no significant changes in lipid profiles, creatinine, and albumin.
Ramadan fasting has significant effects on several biochemical parameters and biological markers in early-stage CKD patients. These changes indicate potential improvements in oxidative stress, cell autophagy, inflammation regulation, and circadian rhythm. Further studies are needed to evaluate the long-term effects and clinical implications of these findings in CKD management.
慢性肾脏病（CKD）是一个全球健康问题，其患病率不断上升。本研究旨在分析斋月禁食对CKD患者重要生物标志物的影响。
对30例1、2和3A期的CKD患者进行前瞻性队列研究，这些患者进行了斋月禁食。在禁食前、禁食期间2周和禁食后，采用酶联免疫吸附测定（ELISA）法测量丙二醛（MDA）、聚（ADP-核糖）聚合酶（PARP）、沉默信息调节因子1（SIRT1）、核受体亚家族1D组第1个成员（NR1D1）和转化生长因子-β（TGF-β）水平。
尿素、空腹血糖、糖化血红蛋白（HbA1C）和尿酸水平显著降低（p<0.05）。MDA和SIRT1显著降低（p<0.001），而PARP和NR1D1显著升高（p<0.001）。TGF-β也呈下降趋势。血脂、肌酐和白蛋白无显著变化。
斋月禁食对早期CKD患者的几个生化参数和生物标志物有显著影响。这些变化表明在氧化应激、细胞自噬、炎症调节和昼夜节律方面可能有所改善。需要进一步研究来评估这些发现对CKD管理的长期影响和临床意义。
