Dundar Bilge, Adsay N Volkan, Allende Daniela S, Jenkins Sarah M, Pai Rish K, Passow Marie R, Reid Michelle D, Westerhoff Maria, Zen Yoh, Graham Rondell P
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Department of Pathology, Koç University Hospital, Istanbul, Turkey.
Histopathology. 2025 Jul 10. doi: 10.1111/his.15511.
Mucinous cystic neoplasms (MCN) are defined by the presence of an ovarian-type stroma (OTS). Once ovarian stroma has become a requirement for the diagnosis of MCNs, studies using this criterion have disclosed that MCNs are seen almost exclusively (97%) in women. The occurrence of MCNs (with ovarian stroma) in men is exceedingly rare and raises questions about the origin of OTS and the role of hormones in tumourigenesis. This study aims to investigate the clinical and histopathological features of pancreatic or hepatic MCNs in men.
We examined the MCN cases in men and compared them with age-matched women. We further investigated MCN in premenopausal and postmenopausal women to explore the impact of hormonal status. The stromal cellularity tended to be lower in men as compared to women; however, limited numbers prevented statistical significance. Clinical presentation, tumour location, body mass index and cyst complexity were similar between men and age-matched women, similarly in pre- and postmenopausal woman groups. All MCN cases, regardless of gender or hormonal status, showed OTS with positivity for oestrogen receptor (ER), androgen receptor (AR) and SF-1 immunostains. Additionally, the presence of AR and ER-beta in lining epithelial cells, in addition to the stromal cells, raised the probability for a potential role for local hormonal signalling in the pathogenesis of these tumours.
MCNs in men had overlapping histopathologic and immunohistochemical profiles with those in women, regardless of menopausal status.
黏液性囊性肿瘤（MCN）的定义是存在卵巢型间质（OTS）。一旦卵巢间质成为MCN诊断的必要条件，采用该标准的研究表明，MCN几乎仅见于女性（97%）。男性发生MCN（伴有卵巢间质）极为罕见，这引发了关于OTS起源以及激素在肿瘤发生中作用的问题。本研究旨在调查男性胰腺或肝脏MCN的临床和组织病理学特征。
我们检查了男性的MCN病例，并将其与年龄匹配的女性进行比较。我们进一步研究了绝经前和绝经后女性的MCN，以探讨激素状态的影响。与女性相比，男性的间质细胞密度往往较低；然而，样本数量有限，无法得出统计学意义。男性与年龄匹配的女性之间，以及绝经前和绝经后女性组之间，临床表现、肿瘤位置、体重指数和囊肿复杂性相似。所有MCN病例，无论性别或激素状态如何，均显示OTS雌激素受体（ER）、雄激素受体（AR）和SF-1免疫染色呈阳性。此外，除了间质细胞外，衬里上皮细胞中也存在AR和ER-β，这增加了局部激素信号在这些肿瘤发病机制中发挥潜在作用的可能性。
无论绝经状态如何，男性MCN的组织病理学和免疫组化特征与女性重叠。
