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iACT4IBD:一项基于接纳与承诺疗法的简短在线干预对改善炎症性肠病成年患者幸福感的随机对照试验。

iACT4IBD: a randomised controlled trial of a brief online intervention based on acceptance and commitment therapy to improve wellbeing for adults with inflammatory bowel disease.

作者信息

Lin Karen, Cavadino Alana, Ow Maggie, Douglas Meihana, Serlachius Anna

机构信息

Department of Psychological Medicine, University of Auckland, Auckland, New Zealand.

Department of Epidemiology and Biostatistics, University of Auckland, Auckland, New Zealand.

出版信息

Front Digit Health. 2025 Jun 26;7:1587765. doi: 10.3389/fdgth.2025.1587765. eCollection 2025.

Abstract

INTRODUCTION

Inflammatory bowel disease (IBD) is associated with high rates of depression and anxiety. Acceptance and Commitment Therapy (ACT) has demonstrated utility across different chronic health conditions, and online ACT interventions may potentially improve access to mental health support.

METHODS

This study was a parallel two-arm randomised controlled trial that investigated the effects a brief seven-day online ACT intervention (iACT4IBD) on psychological and physical health outcomes. We examined whether iACT4IBD could reduce depressive symptoms in adults with IBD compared to a waitlist control group at 4-weeks follow-up. Effects of iACT4IBD on levels of anxiety, stress, wellbeing, quality of life, and IBD activity were also explored. Seventy adults with IBD (Crohn's disease and ulcerative colitis) were randomly allocated to either the iACT4IBD intervention or a waitlist control group. Psychological and physical health outcomes were collected at baseline, 4-weeks and 8-weeks after baseline. Outcome measures were assessed at baseline and 4-weeks follow-up using mixed ANOVAs.

RESULTS

No between-group differences in psychological outcomes were found from baseline to 4-weeks follow-up. Crohn's disease activity scores in the intervention group were significantly lower after 4-weeks compared to the waitlist control group. Qualitative feedback suggested that the intervention was acceptable and beneficial.

DISCUSSION

There were no improvements to mental wellbeing; however, findings provided some support for the intervention improving physical health in people with Crohn's disease. Further research is needed.

CLINICAL TRIAL REGISTRATION

Australian New Zealand Clinical Trials Registry (U1111-1282-2334).

摘要

引言

炎症性肠病(IBD)与抑郁症和焦虑症的高发病率相关。接纳与承诺疗法(ACT)已在不同的慢性健康状况中显示出效用,在线ACT干预可能会改善心理健康支持的可及性。

方法

本研究是一项平行双臂随机对照试验,调查了为期七天的简短在线ACT干预(iACT4IBD)对心理和身体健康结果的影响。我们研究了与等待名单对照组相比,iACT4IBD在4周随访时是否能减轻IBD成人患者的抑郁症状。还探讨了iACT4IBD对焦虑、压力、幸福感、生活质量和IBD活动水平的影响。70名患有IBD(克罗恩病和溃疡性结肠炎)的成年人被随机分配到iACT4IBD干预组或等待名单对照组。在基线、基线后4周和8周收集心理和身体健康结果。在基线和4周随访时使用混合方差分析评估结果指标。

结果

从基线到4周随访,未发现心理结果的组间差异。与等待名单对照组相比,干预组在4周后的克罗恩病活动评分显著更低。定性反馈表明该干预是可接受且有益的。

讨论

心理健康状况没有改善;然而,研究结果为该干预改善克罗恩病患者的身体健康提供了一些支持。需要进一步研究。

临床试验注册

澳大利亚新西兰临床试验注册中心(U1111 - 1282 - 2334)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fe6/12241075/a1eb1fd5bd38/fdgth-07-1587765-g001.jpg

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