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激素和非激素阴道凝胶制剂对性功能障碍综合征绝经后女性性满意度指数的疗效：

Efficacy of Hormonal and Non-Hormonal Vaginal Gel Preparations on the Female Sexual Satisfaction Index in Postmenopausal Women with Sexual Dysfunction Syndrome: .

作者信息

Soliman Ahmed, Alrashidi Hanaa, Mohamed Mohamed A, Ghorab Reem, Al Riyami Nihal, Ashour Ahmed S A, Mohammed Yasmine A, Saad Ahmed H

机构信息

Faculty of Medicine, Research Department, Mansoura University, Mansoura, Egypt.

Mansoura Research Team (MRT), Research Department, Mansoura University, Mansoura, Egypt.

出版信息

Sultan Qaboos Univ Med J. 2025 May 2;25(1):17-28. doi: 10.18295/squmj.6.2024.00.

DOI:10.18295/squmj.6.2024.00
PMID:40641729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12244233/
Abstract

This meta-analysis aimed to compare the efficacy of vaginal gel preparations versus placebo in postmenopausal women with sexual dysfunction syndrome. Searches of electronic databases from inception to January 2023 identified 8 trials (N = 672) that reported the Female Sexual Function Index (FSFI) and compared hormonal (oestrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions against placebo. The Cochrane Risk of Bias tool was used to assess studies' quality. The vaginal gel group had a significantly higher total FSFI endpoint score (mean difference [MD] = 6.67, 95% confidence interval [CI]: 3.79-9.55; < 0.001) than placebo. Non-hormonal gels exhibited a greater FSFI total score (MD = 6.73, 95% CI: 4.7-8.76; < 0.001) than hormonal gels (MD = 2.75, 95% CI: 1.87-3.64; < 0.001), positively impacting all FSFI domains. These findings indicate that chamomile and fennel vaginal gels may improve the overall FSFI 6 domains score, reflecting enhancements in postmenopausal women's sexual activity and satisfaction.

摘要

这项荟萃分析旨在比较阴道凝胶制剂与安慰剂对性功能障碍综合征绝经后女性的疗效。检索从数据库建立至2023年1月的电子数据库，共识别出8项试验（N = 672），这些试验报告了女性性功能指数（FSFI），并比较了激素（雌激素、催产素）和/或非激素（洋甘菊、茴香）干预措施与安慰剂的效果。采用Cochrane偏倚风险工具评估研究质量。阴道凝胶组的FSFI总终点得分显著高于安慰剂组（平均差[MD]=6.67，95%置信区间[CI]：3.79 - 9.55；P<0.001）。非激素凝胶的FSFI总分（MD = 6.73，95% CI：4.7 - 8.76；P<0.001）高于激素凝胶（MD = 2.75，95% CI：1.87 - 3.64；P<0.001），对所有FSFI领域均有积极影响。这些发现表明，洋甘菊和茴香阴道凝胶可能会提高FSFI 6个领域的总体得分，反映出绝经后女性性活动和满意度的提高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4440/12244233/fcdffd9fae0f/squmj_v25_n01_squmj6448-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4440/12244233/934c0f627e71/squmj_v25_n01_squmj6448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4440/12244233/fcdffd9fae0f/squmj_v25_n01_squmj6448-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4440/12244233/934c0f627e71/squmj_v25_n01_squmj6448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4440/12244233/fcdffd9fae0f/squmj_v25_n01_squmj6448-g002.jpg

相似文献

[1]
Efficacy of Hormonal and Non-Hormonal Vaginal Gel Preparations on the Female Sexual Satisfaction Index in Postmenopausal Women with Sexual Dysfunction Syndrome: .

Sultan Qaboos Univ Med J. 2025-5-2

[2]
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[7]
Effect of Chamomile Vaginal Gel on the Sexual Function in Postmenopausal Women: A Double-Blind Randomized Controlled Trial.

J Sex Med. 2022-6

[8]
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[9]
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[10]
Local oestrogen for vaginal atrophy in postmenopausal women.

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本文引用的文献

[1]
Female sexual function index for screening of female sexual dysfunction using DSM-5-TR criteria in Thai women: A prospective cross-sectional diagnostic study.

PLoS One. 2024

[2]
Postmenopausal women's usage of complementary and alternative medicine and its relationship to sexual function: A cross-sectional study in southeastern Iran.

Health Sci Rep. 2023-8-1

[3]
Hormone therapy for sexual function in perimenopausal and postmenopausal women: a systematic review and meta-analysis update.

Menopause. 2023-6-1

[4]
Adherence to the Mediterranean Diet: Impact of Geographical Location of the Observations.

Nutrients. 2022-5-13

[5]
Effect of Chamomile Vaginal Gel on the Sexual Function in Postmenopausal Women: A Double-Blind Randomized Controlled Trial.

J Sex Med. 2022-6

[6]
The effect of intra-vaginal oxytocin on sexual function in breastfeeding mothers: a randomized triple-blind placebo-controlled trial.

BMC Pregnancy Childbirth. 2022-1-22

[7]
Essential Oil of Mill. as a Green Fungicide and Defense-Inducing Agent against Fusarium Root Rot Disease in L.

Biology (Basel). 2021-7-22

[8]
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.

BMJ. 2021-3-29

[9]
Effect of estradiol vaginal gel on vaginal atrophy in postmenopausal women: A randomized double-blind controlled trial.

J Obstet Gynaecol Res. 2020-8

[10]
The Impact of Oxytocin Vaginal Gel on Sexual Function in Postmenopausal Women: A Randomized Controlled Trial.

J Sex Marital Ther. 2020

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