Soliman Ahmed, Alrashidi Hanaa, Mohamed Mohamed A, Ghorab Reem, Al Riyami Nihal, Ashour Ahmed S A, Mohammed Yasmine A, Saad Ahmed H
Faculty of Medicine, Research Department, Mansoura University, Mansoura, Egypt.
Mansoura Research Team (MRT), Research Department, Mansoura University, Mansoura, Egypt.
Sultan Qaboos Univ Med J. 2025 May 2;25(1):17-28. doi: 10.18295/squmj.6.2024.00.
This meta-analysis aimed to compare the efficacy of vaginal gel preparations versus placebo in postmenopausal women with sexual dysfunction syndrome. Searches of electronic databases from inception to January 2023 identified 8 trials (N = 672) that reported the Female Sexual Function Index (FSFI) and compared hormonal (oestrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions against placebo. The Cochrane Risk of Bias tool was used to assess studies' quality. The vaginal gel group had a significantly higher total FSFI endpoint score (mean difference [MD] = 6.67, 95% confidence interval [CI]: 3.79-9.55; < 0.001) than placebo. Non-hormonal gels exhibited a greater FSFI total score (MD = 6.73, 95% CI: 4.7-8.76; < 0.001) than hormonal gels (MD = 2.75, 95% CI: 1.87-3.64; < 0.001), positively impacting all FSFI domains. These findings indicate that chamomile and fennel vaginal gels may improve the overall FSFI 6 domains score, reflecting enhancements in postmenopausal women's sexual activity and satisfaction.
这项荟萃分析旨在比较阴道凝胶制剂与安慰剂对性功能障碍综合征绝经后女性的疗效。检索从数据库建立至2023年1月的电子数据库，共识别出8项试验（N = 672），这些试验报告了女性性功能指数（FSFI），并比较了激素（雌激素、催产素）和/或非激素（洋甘菊、茴香）干预措施与安慰剂的效果。采用Cochrane偏倚风险工具评估研究质量。阴道凝胶组的FSFI总终点得分显著高于安慰剂组（平均差[MD]=6.67，95%置信区间[CI]：3.79 - 9.55；P<0.001）。非激素凝胶的FSFI总分（MD = 6.73，95% CI：4.7 - 8.76；P<0.001）高于激素凝胶（MD = 2.75，95% CI：1.87 - 3.64；P<0.001），对所有FSFI领域均有积极影响。这些发现表明，洋甘菊和茴香阴道凝胶可能会提高FSFI 6个领域的总体得分，反映出绝经后女性性活动和满意度的提高。
