Blanchard Ana C, Zahradnik Stephanie, Isabel Sandra, Mehta Kayur, Ali Mohsin, Airo Adriana, Streitenberger Laurie, Freeman Renee, Yau Yvonne Cw, Campigotto Aaron, Tadros Manal, Science Michelle
Division of Infectious Diseases, Department of Paediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada.
Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
J Assoc Med Microbiol Infect Dis Can. 2024 Jul 19;9(2):104-107. doi: 10.3138/jammi-2023-0037. eCollection 2024 Jun.
The epidemiology of carbapenemase-producing Enterobacterales (CPE) in hospitalized children in low endemicity settings is not well known. We aim to describe it in a large tertiary paediatric health care centre in Canada.
A repeated point-prevalence study including all inpatients was conducted at the Hospital for Sick Children, Toronto, for surveillance purposes over 3 days serially in April 2017, April 2019, and April 2022. Patients in the emergency department and medical day units were excluded. Stools or rectal swabs were analyzed for CPE identification, with confirmatory testing at the provincial reference laboratory.
We detected CPE colonization in 0.4% (1/242), 0.7% (2/278), and 0.9% (2/220) of inpatients in 2017, 2019, and 2022, respectively. Identified CPE included OXA-48-like and NDM beta-lactamases in and . All patients with CPE colonization had a history of travel or hospitalization outside of Canada, including in the Middle East and Asia.
CPE colonization in children hospitalized in this Canadian hospital was detected. A history of prolonged travel or hospitalization outside of Canada are risk factors that should be considered in targeted screening programs.
在低流行地区的住院儿童中，产碳青霉烯酶肠杆菌科细菌（CPE）的流行病学情况尚不清楚。我们旨在描述加拿大一家大型三级儿科医疗中心的相关情况。
2017年4月、2019年4月和2022年4月，在多伦多病童医院连续3天进行了一项重复的点患病率研究，纳入所有住院患者以进行监测。急诊科和医疗日间病房的患者被排除。对粪便或直肠拭子进行分析以鉴定CPE，并在省级参考实验室进行确证检测。
2017年、2019年和2022年住院患者中CPE定植的检出率分别为0.4%（1/242）、0.7%（2/278）和0.9%（2/220）。鉴定出的CPE包括[具体年份1]中的OXA - 48样和NDMβ - 内酰胺酶以及[具体年份]中的[具体酶型]。所有CPE定植患者都有在加拿大境外旅行或住院的历史，包括中东和亚洲。
在这家加拿大医院住院的儿童中检测到了CPE定植。在针对性筛查项目中应考虑在加拿大境外长时间旅行或住院的历史作为风险因素。
