Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Department of Orthopedics and Trauma, Peking University People's Hospital, Key Laboratory of Trauma and Neural Regeneration, Peking University, National Center for Trauma Medicine, Qingdao Hospital, Peking University People's Hospital, Beijing, 100044, China.
Adv Mater. 2024 Feb;36(8):e2310164. doi: 10.1002/adma.202310164. Epub 2023 Dec 8.
Hydrogel adhesion materials are widely reported for tissue engineering repair applications, however, wet tissue surface moisture can reduce the wet-adhesion properties and mechanical strength of hydrogels limiting their application. Here, anti-hydration gelatin-acrylic acid-ethylene dimethacrylate (GAE) hydrogels with hydrophobic cross-linked chains are constructed. The prepared GAE hydrogel is soaked in PBS (3 days) with a volume change of 0.6 times of the original and the adhesive strength, Young's modulus, toughness, and burst pressure are maintained by ≈70% of the original. A simple and universal method is used to introduce hydrophobic chains as cross-linking points to prepare hydrogels with anti-hydration, toughness, and high wet state adhesion. The hydrophobic cross-linked chains not only restrict the movement of molecular chains but also hinder the intrusion of water molecules. Antihydration GAE hydrogels exhibit good biocompatibility, slow drug release, and dynamic oral wet-state tissue repair properties. Therefore, the anti-hydration hydrogel has excellent toughness, wet tissue adhesion properties, and good prospects for biological applications.
水凝胶粘附材料在组织工程修复应用中得到了广泛的报道，然而，湿组织表面的水分会降低水凝胶的湿粘附性能和机械强度，限制其应用。在这里，构建了具有疏水交联链的抗水化明胶-丙烯酸-乙二甲基丙烯酸酯（GAE）水凝胶。所制备的 GAE 水凝胶在 PBS 中浸泡（3 天），体积变化为原始体积的 0.6 倍，其粘附强度、杨氏模量、韧性和爆裂压力保持在原始值的约 70%。使用一种简单而通用的方法引入疏水链作为交联点，制备具有抗水化、韧性和高湿态粘附性的水凝胶。疏水交联链不仅限制了分子链的运动，而且阻碍了水分子的侵入。抗水化 GAE 水凝胶表现出良好的生物相容性、缓慢的药物释放以及动态口腔湿性组织修复性能。因此，该抗水化水凝胶具有优异的韧性、湿组织粘附性能，在生物应用方面具有广阔的前景。
