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婴儿面临的三个挑战:神经母细胞瘤酷似婴儿肝血管瘤,伴有乳糜胸及胸腔积液中的菊形团。

Three Challenges in an Infant: Neuroblastoma Mimicking Infantile Hepatic Hemangioma, With Chylothorax and Rosettes in Pleural Fluid.

作者信息

Alavi Samin, Khalili Mitra, Aghdam Maryam Kazemi, Zamani Alireza, Madani Tahereh

机构信息

Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Pediatric Radiology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Case Rep Hematol. 2025 Jul 3;2025:9948246. doi: 10.1155/crh/9948246. eCollection 2025.

Abstract

Infantile hepatic hemangioma (IHH) is rare, but the most common benign hepatic tumor in the first year of life. It has a characteristic course with perinatal presentation, increasing growth during the first year of life, and subsequent shrinkage of the vascular lesions. The authors report a 12-month-old male infant who presented with severe abdominal distension and respiratory distress while under workup for diffuse IHH since 2 months of age. In addition, the child's situation was complicated by two uncommon occurrences: bilateral chylothorax and the presence of neuroblasts and rosette cells in the pleural fluid. The detection of such cells in pleural fluid is extremely rare in pediatric neuroblastoma cases. This complex medical scenario highlights the challenges faced in diagnosing and managing rare pediatric conditions, emphasizing the need for careful monitoring and comprehensive diagnostic approaches in similar cases.

摘要

婴儿肝血管瘤(IHH)较为罕见,但却是出生后第一年最常见的肝脏良性肿瘤。它具有典型病程,在围产期出现,出生后第一年生长加快,随后血管病变缩小。作者报告了一名12个月大的男婴,自2个月大起因弥漫性IHH接受检查时出现严重腹胀和呼吸窘迫。此外,该患儿的情况因两种罕见情况而复杂化:双侧乳糜胸以及胸腔积液中存在神经母细胞和玫瑰花结细胞。在小儿神经母细胞瘤病例中,胸腔积液中检测到此类细胞极为罕见。这种复杂的医疗情况凸显了诊断和管理罕见儿科疾病所面临的挑战,强调了在类似病例中进行仔细监测和综合诊断方法的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9070/12245509/f854f8d71fc9/CRIHEM2025-9948246.001.jpg

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